Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy

Overview

Journal Ann Surg Oncol

Publisher Springer

Specialty Oncology

Date 2017 Apr 12

PMID 28397189

Citations 43

Authors

Marc El Beaino

Dejka M Araujo

Alexander J Lazar

Patrick P Lin

Affiliations

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Abstract

Synovial sarcoma is a translocation-associated soft-tissue malignancy that frequently affects adolescents and young adults. It is driven by one of the fusion oncoproteins SS18-SSX1, SS18-SSX2, or rarely, SS18-SSX4. Prognosis of patients with recurrent or metastatic disease is generally poor, and newer therapeutic strategies are needed. In this review, we present recent discoveries in the pathogenesis, diagnosis, and treatment of synovial sarcoma. We discuss potential therapeutic strategies to improve clinical outcomes in this disease.

Citing Articles

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