Dynamic Expression of the BabA Adhesin and Its BabB Paralog During Helicobacter Pylori Infection in Rhesus Macaques

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2017 Apr 12

PMID 28396320

Citations 8

Authors

Lori M Hansen

Par Gideonsson

Don R Canfield

Thomas Boren

Jay V Solnick

Affiliations

Soon will be listed here.

Abstract

Most strains express the BabA adhesin, which binds to ABO/Leb blood group antigens on gastric mucin and epithelial cells and is found more commonly in strains that cause peptic ulcers or gastric cancer, rather than asymptomatic infection. We and others have previously reported that in mice, gerbils, and rhesus macaques, expression of is lost, either by phase variation or by gene conversion, in which the paralog recombines into the locus. The functional significance of loss of expression is unknown. Here we report that in rhesus monkeys, there is independent selective pressure for loss of and for overexpression of BabB, which confers a fitness advantage. Surprisingly, loss of by phase variation or gene conversion is not dependent on the capacity of BabA protein to bind Leb, which suggests that it may have other, unrecognized functions. These findings have implications for the role of outer membrane protein diversity in persistent infection.

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