Down-regulation of MiR-125a-5p is Associated with Salivary Adenoid Cystic Carcinoma Progression Via Targeting P38/JNK/ERK Signal Pathway

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2017 Apr 8

PMID 28386337

Citations 11

Authors

Yancan Liang

Jiantao Ye

Jiuyang Jiao

Jin Zhang

Yingjuan Lu

Li Zhang

Di Wan

Liming Duan

You Wu

Bin Zhang

Affiliations

Soon will be listed here.

Abstract

Salivary adenoid cystic carcinoma (SACC) is a relatively uncommon epithelial-like malignancy that can occur in the head and neck region. Despite its slow growth, this aggressive salivary gland tumor frequently recurs and metastasizes to distant organs since lacking effective chemotherapy treatment. MicroRNAs are key regulators in tumor metastasis and progression, but their roles during SACC progression have not been illustrated. In current study, we demonstrate that miR-125a-5p is down-regulated in SACC and closely related to the metastasis and progression in human SACC specimens. In vitro, miR-125a-5p mimic can suppress SACC cell migration and invasion; while blocking miR-125a-5p can relieve the inhibition effect. By using dual-luciferase assay, we confirmed that miR-125a-5p directly targeted to p38 and tissue samples of patients indicated the negative correlation between miR-125a-5p and p38; clinical analysis also showed that low level expression of miR-125a-5p is closely associated with poor prognosis of SACC. Furthermore, down-regulation of miR-125a-5p triggered downstream p38/JNK/ERK activation. Taken together, our results indicate that down-regulation of miR-125a-5p promotes SACC progression through p38 signal pathway and miR-125a-5p can be a potential therapeutic target of SACC.

Citing Articles

Comparison of miRNA Profiles of Primary Tumors and Metastatic Tumors of Salivary Gland Tumors and Their Role in Prognosis: A Systematic Review.

Mohtasham N, Tarrah M, Arab F, Sadeghi M, Mohajertehran F Iran J Public Health. 2024; 53(9):1992-2005.

PMID: 39429675 PMC: 11490322. DOI: 10.18502/ijph.v53i9.16453.

Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets.

Kimura T, de Lima-Souza R, Maciel T, Kowalski L, Coutinho-Camillo C, Egal E Head Neck Pathol. 2024; 18(1):12.

PMID: 38393615 PMC: 10891027. DOI: 10.1007/s12105-023-01603-4.

MicroRNA in adenoid cystic carcinoma (Review).

Li Y, Gu F, He Y, Xiang J, Huang X, Wang Y Int J Oncol. 2022; 62(1).

PMID: 36484384 PMC: 9747198. DOI: 10.3892/ijo.2022.5465.

Reconstruction and analysis of the aberrant lncRNA-miRNA-mRNA network based on competitive endogenous RNA in adenoid cystic carcinoma of the salivary gland.

Tang Y, Wu W, Zhang J, Zhang J Transl Cancer Res. 2022; 10(12):5133-5149.

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Diagnostic and prognostic value of miRNAs on salivary gland tumors: a systematic review and meta-analysis.

Santana Dos Santos E, Normando A, Scarini J, Crescencio L, de Lima-Souza R, Mariano F Oral Maxillofac Surg. 2021; 25(4):445-456.

PMID: 33666770 DOI: 10.1007/s10006-021-00952-0.

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