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Discrete Multi-physics: A Mesh-free Model of Blood Flow in Flexible Biological Valve Including Solid Aggregate Formation

Overview
Journal PLoS One
Specialties General Medicine
Science
Date 2017 Apr 7
PMID 28384341
Citations 10
Authors
Mostapha Ariane
Mohamed Hatem Allouche
Marco Bussone
Fausto Giacosa
Frederic Bernard
Mostafa Barigou
Alessio Alexiadis
Affiliations
Soon will be listed here.
Abstract

We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves.

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