In-hospital Outcomes of Premature Infants with Severe Bronchopulmonary Dysplasia

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2017 Apr 7

PMID 28383537

Citations 8

Authors

W Jackson

C P Hornik

J A Messina

K Guglielmo

A Watwe

G Delancy

A Valdez

T MacArthur

S Peter-Wohl

P B Smith

V N Tolia

M M Laughon

Affiliations

Soon will be listed here.

Abstract

Objective: To characterize in-hospital outcomes of premature infants diagnosed with severe bronchopulmonary dysplasia (BPD).

Study Design: Retrospective cohort study including premature infants with severe BPD discharged from 348 Pediatrix Medical Group neonatal intensive care units from 1997 to 2015.

Results: There were 10 752 infants with severe BPD, and 549/10 752 (5%) died before discharge. Infants who died were more likely to be male, small for gestational age, have received more medical interventions and more frequently diagnosed with surgical necrotizing enterocolitis, culture-proven sepsis and pulmonary hypertension following 36 weeks of postmenstrual age compared with survivors. Approximately 70% of infants with severe BPD were discharged by 44 weeks of postmenstrual age, and 86% were discharged by 48 weeks of postmenstrual age.

Conclusions: A majority of infants diagnosed with severe BPD were discharged home by 44 weeks of postmenstrual age. These results may inform discussions with families regarding the expected hospital course of infants diagnosed with severe BPD.

Citing Articles

Exploring the Association of Male Sex With Adverse Outcomes in Severe Bronchopulmonary Dysplasia: A Retrospective, Multicenter Cohort Study.

Hammond 2nd J, Kielt M, Conroy S, Lingappan K, Austin E, Eldredge L Chest. 2023; 165(3):610-620.

PMID: 37879559 PMC: 11242927. DOI: 10.1016/j.chest.2023.10.020.

Mechanical ventilation characteristics and their prediction performance for the risk of moderate and severe bronchopulmonary dysplasia in infants with gestational age <30 weeks and birth weight <1,500 g.

Yin J, Liu L, Li H, Hou X, Chen J, Han S Front Pediatr. 2022; 10:993167.

PMID: 36405843 PMC: 9666736. DOI: 10.3389/fped.2022.993167.

Risk factors that affect the degree of bronchopulmonary dysplasia in very preterm infants: a 5-year retrospective study.

Yang T, Shen Q, Wang S, Dong T, Liang L, Xu F BMC Pediatr. 2022; 22(1):200.

PMID: 35413820 PMC: 9004103. DOI: 10.1186/s12887-022-03273-7.

Ventilatory Strategies in Infants with Established Severe Bronchopulmonary Dysplasia: A Multicenter Point Prevalence Study.

McKinney R, Napolitano N, Levin J, Kielt M, Abman S, Guaman M J Pediatr. 2021; 242:248-252.e1.

PMID: 34710394 PMC: 10478127. DOI: 10.1016/j.jpeds.2021.10.036.

Efficacy of budesonide in the prevention and treatment of bronchopulmonary dysplasia in premature infants and its effect on pulmonary function.

Yao Y, Zhang G, Wang F, Wang M Am J Transl Res. 2021; 13(5):4949-4958.

PMID: 34150079 PMC: 8205685.

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