Characteristics of PR Interval As Predictor for Atrial Fibrillation: Association with Biomarkers and Outcomes

Overview

Journal Clin Res Cardiol

Specialty Cardiology & Vascular Diseases

Date 2017 Apr 7

PMID 28382425

Citations 26

Authors

Katja Schumacher

Nikolaos Dagres

Gerhard Hindricks

Daniela Husser

Andreas Bollmann

Jelena Kornej

Affiliations

Soon will be listed here.

Abstract

The PR interval may be considered as a simple and easily obtainable predictor for adverse events, including atrial fibrillation (AF), pacemaker implantation, and mortality. Interestingly, both high and low extremes of the PR duration are associated with AF risk. However, the results regarding PR prolongation as a risk factor for AF are inconsistent. Some studies have analyzed the impact of P duration (as a part of the PR interval) and demonstrated that the P-duration contributes to the length of PR interval and adverse outcomes. The PR prolongation could be considered as a marker for cardiovascular degenerative aging caused by myocardial fibrosis and vascular inflammation. Furthermore, due to PR prolongation chronically raised intra-atrial pressure and consequential neuro-hormonal activation predispose systemic vascular endothelial dysfunction and explain the associations with adverse vascular events. In this review, we discuss the association between biomarkers with PR interval in AF.

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