Imaginal Disc Regeneration Takes Flight

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2017 Apr 5

PMID 28376317

Citations 40

Authors

Iswar K Hariharan

Florenci Serras

Affiliations

Soon will be listed here.

Abstract

Drosophila imaginal discs, the larval precursors of adult structures such as the wing and leg, are capable of regenerating after damage. During the course of regeneration, discs can sometimes generate structures that are appropriate for a different type of disc, a phenomenon termed transdetermination. Until recently, these phenomena were studied by physically fragmenting discs and then transplanting them into the abdomens of adult female flies. This field has experienced a renaissance following the development of genetic ablation systems that can damage precisely defined regions of the disc without the need for surgery. Together with more traditional approaches, these newer methods have generated many novel insights into wound healing, the mechanisms that drive regenerative growth, plasticity during regeneration and systemic effects of tissue damage and regeneration.

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References

Reinhardt C, Hodgkin N, Bryant P . Wound healing in the imaginal discs of Drosophila. I. Scanning electron microscopy of normal and healing wing discs. Dev Biol. 1977; 60(1):238-57. DOI: 10.1016/0012-1606(77)90122-1. View

Jaszczak J, Wolpe J, Dao A, Halme A . Nitric Oxide Synthase Regulates Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration. Genetics. 2015; 200(4):1219-28. PMC: 4574233. DOI: 10.1534/genetics.115.178053. View

Schubiger G . Regeneration, duplication and transdetermination in fragments of the leg disc of Drosophila melanogaster. Dev Biol. 1971; 26(2):277-95. DOI: 10.1016/0012-1606(71)90127-8. View

Blanco E, Ruiz-Romero M, Beltran S, Bosch M, Punset A, Serras F . Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. BMC Dev Biol. 2010; 10:94. PMC: 2939566. DOI: 10.1186/1471-213X-10-94. View

Szabad J, Simpson P, Nothiger R . Regeneration and compartments in Drosophila. J Embryol Exp Morphol. 1979; 49:229-41. View

Bryant P, Fraser S . Wound healing, cell communication, and DNA synthesis during imaginal disc regeneration in Drosophila. Dev Biol. 1988; 127(1):197-208. DOI: 10.1016/0012-1606(88)90201-1. View

Skinner A, Khan S, Smith-Bolton R . Trithorax regulates systemic signaling during Drosophila imaginal disc regeneration. Development. 2015; 142(20):3500-11. PMC: 6514394. DOI: 10.1242/dev.122564. View

Boone E, Colombani J, Andersen D, Leopold P . The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression. Nat Commun. 2016; 7:13505. PMC: 5121414. DOI: 10.1038/ncomms13505. View

Herrera S, Martin R, Morata G . Tissue homeostasis in the wing disc of Drosophila melanogaster: immediate response to massive damage during development. PLoS Genet. 2013; 9(4):e1003446. PMC: 3636033. DOI: 10.1371/journal.pgen.1003446. View

10.

Wells B, Yoshida E, Johnston L . Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr Biol. 2006; 16(16):1606-15. PMC: 1764442. DOI: 10.1016/j.cub.2006.07.046. View

11.

Schubiger M, Sustar A, Schubiger G . Regeneration and transdetermination: the role of wingless and its regulation. Dev Biol. 2010; 347(2):315-24. PMC: 2976676. DOI: 10.1016/j.ydbio.2010.08.034. View

12.

Bergantinos C, Vilana X, Corominas M, Serras F . Imaginal discs: Renaissance of a model for regenerative biology. Bioessays. 2010; 32(3):207-217. DOI: 10.1002/bies.200900105. View

13.

Haynie J, Bryant P . Intercalary regeneration in imaginal wing disk of Drosophila melanogaster. Nature. 1976; 259(5545):659-62. DOI: 10.1038/259659b0. View

14.

Harris R, Setiawan L, Saul J, Hariharan I . Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs. Elife. 2016; 5. PMC: 4786413. DOI: 10.7554/eLife.11588. View

15.

Schubiger G, Hadorn E . [Auto- and allotypic differentiation in vivo cultivated foreleg blastemas of Drosophila melanogaster]. Dev Biol. 1968; 17(5):584-602. DOI: 10.1016/0012-1606(68)90007-9. View

16.

Klebes A, Sustar A, Kechris K, Li H, Schubiger G, Kornberg T . Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes. Development. 2005; 132(16):3753-65. DOI: 10.1242/dev.01927. View

17.

Garcia-Bellido A, Ripoll P, Morata G . Developmental compartmentalisation of the wing disk of Drosophila. Nat New Biol. 1973; 245(147):251-3. DOI: 10.1038/newbio245251a0. View

18.

Halme A, Cheng M, Hariharan I . Retinoids regulate a developmental checkpoint for tissue regeneration in Drosophila. Curr Biol. 2010; 20(5):458-63. PMC: 2847081. DOI: 10.1016/j.cub.2010.01.038. View

19.

Bosch M, Baguna J, Serras F . Origin and proliferation of blastema cells during regeneration of Drosophila wing imaginal discs. Int J Dev Biol. 2008; 52(8):1043-50. DOI: 10.1387/ijdb.082608mb. View

20.

Jaszczak J, Wolpe J, Bhandari R, Jaszczak R, Halme A . Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland. Genetics. 2016; 204(2):703-709. PMC: 5068856. DOI: 10.1534/genetics.116.193706. View