Outpatient Emergencies: Anaphylaxis
Overview
Authors
Affiliations
Anaphylactic fatalities are rare; however, mild reactions can rapidly progress to cardiovascular and respiratory arrest. The clinical course of anaphylaxis can be unpredictable. Prompt and early use of epinephrine should be considered. Most anaphylaxis episodes have an immunologic mechanism involving immunoglobulin E (IgE). Foods are the most common cause in children; medications and insect stings are more common in adults. When the cause is not completely avoidable or cannot be determined, a patient should be supplied with autoinjectable epinephrine and be instructed its use. They should keep the device with them at all times and taught the signs and symptoms of anaphylaxis.
A Clinical Practice Guideline for the Emergency Management of Anaphylaxis (2020).
Li X, Ma Q, Yin J, Zheng Y, Chen R, Chen Y Front Pharmacol. 2022; 13:845689.
PMID: 35418863 PMC: 8996305. DOI: 10.3389/fphar.2022.845689.
Pediatric Anaphylaxis: Etiology and Predictive Factors in an Emergency Setting.
Uppala R, Phungoen P, Mairiang D, Chaiyarit J, Techasatian L Glob Pediatr Health. 2021; 8:2333794X211011301.
PMID: 33997122 PMC: 8111268. DOI: 10.1177/2333794X211011301.
LoVerde D, Iweala O, Eginli A, Krishnaswamy G Chest. 2017; 153(2):528-543.
PMID: 28800865 PMC: 6026262. DOI: 10.1016/j.chest.2017.07.033.