Evidence of Autocrine Regulation in Human Hepatoma Cell Lines

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1988 May 31

PMID 2837209

Citations 14

Authors

T F Tsai

Y K Yauk

C K Chou

L. P. Ting

C Chang

C P Hu

S H Han

T S Su

Affiliations

Soon will be listed here.

Abstract

Human hepatoma cell lines were studied for the expression of platelet-derived growth factor (PDGF), insulin-like growth factor-I (IGF-I) and their receptors at the mRNA level. Transcripts of PDGF were consistently detected in these cell lines. In addition, some cell lines also expressed PDGF receptor RNA. Moreover, RNA of IGF-I and its receptor were detected in every cell line examined. These results suggest that autocrine regulation may be an important mechanism for the maintenance of the transformed state of human hepatoma cells.

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