Trichomonas Vaginalis Infection in Symbiosis with Trichomonasvirus and Mycoplasma

Overview

Journal Res Microbiol

Publisher Elsevier

Specialty Microbiology

Date 2017 Apr 4

PMID 28366838

Citations 46

Authors

Raina Fichorova

Jorge Fraga

Paola Rappelli

Pier Luigi Fiori

Affiliations

Soon will be listed here.

Abstract

Trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. This review focuses on symbiotic Trichomonasvirus and mycoplasmas carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. Improved diagnostics and larger clinical interventional studies are needed to confirm the causative role of protozoan symbionts in the variable clinical presentation of trichomoniasis and its morbid sequelae, including adverse reproductive outcome, susceptibility to viral infections and cancer.

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