SP and KLF Transcription Factors in Digestive Physiology And Diseases

Overview

Journal Gastroenterology

Specialty Gastroenterology

Date 2017 Apr 4

PMID 28366734

Citations 53

Authors

Chang-Kyung Kim

Ping He

Agnieszka B Bialkowska

Vincent W Yang

Affiliations

Soon will be listed here.

Abstract

Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription factors that contain conserved zinc finger domains involved in binding to target DNA sequences. Many of these proteins are expressed in different tissues and have distinct tissue-specific activities and functions. Studies have shown that SPs and KLFs regulate not only physiological processes such as growth, development, differentiation, proliferation, and embryogenesis, but pathogenesis of many diseases, including cancer and inflammatory disorders. Consistently, these proteins have been shown to regulate normal functions and pathobiology in the digestive system. We review recent findings on the tissue- and organ-specific functions of SPs and KLFs in the digestive system including the oral cavity, esophagus, stomach, small and large intestines, pancreas, and liver. We provide a list of agents under development to target these proteins.

Citing Articles

Activation of Genes by Nuclear Receptor/Specificity Protein (Sp) Interactions in Cancer.

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Transcription factor specificity protein (SP) family in renal physiology and diseases.

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Transcriptomic response of overexpression ZNF32 in breast cancer cells.

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CircSEC24A induces KLF8 expression to promote the malignant progression of non-small cell lung cancer by regulating miR-1253.

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Fang R, Sha C, Xie Q, Yao D, Yao M Anticancer Agents Med Chem. 2024; 25(2):75-85.

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