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SP and KLF Transcription Factors in Digestive Physiology And Diseases

Overview
Specialty Gastroenterology
Date 2017 Apr 4
PMID 28366734
Citations 53
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Abstract

Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription factors that contain conserved zinc finger domains involved in binding to target DNA sequences. Many of these proteins are expressed in different tissues and have distinct tissue-specific activities and functions. Studies have shown that SPs and KLFs regulate not only physiological processes such as growth, development, differentiation, proliferation, and embryogenesis, but pathogenesis of many diseases, including cancer and inflammatory disorders. Consistently, these proteins have been shown to regulate normal functions and pathobiology in the digestive system. We review recent findings on the tissue- and organ-specific functions of SPs and KLFs in the digestive system including the oral cavity, esophagus, stomach, small and large intestines, pancreas, and liver. We provide a list of agents under development to target these proteins.

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References
1.
Chae J, Jeon Y, Shim J . Anti-proliferative properties of kahweol in oral squamous cancer through the regulation specificity protein 1. Phytother Res. 2014; 28(12):1879-86. DOI: 10.1002/ptr.5217. View

2.
Nandan M, Chanchevalap S, Dalton W, Yang V . Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. FEBS Lett. 2005; 579(21):4757-62. PMC: 1626271. DOI: 10.1016/j.febslet.2005.07.053. View

3.
Chen Y, Chang W, Liu Y, Lee C, Jang Y, Kuo C . A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. Chem Biol Interact. 2009; 181(3):440-6. DOI: 10.1016/j.cbi.2009.07.004. View

4.
Shields J, Christy R, Yang V . Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J Biol Chem. 1996; 271(33):20009-17. PMC: 2330254. DOI: 10.1074/jbc.271.33.20009. View

5.
Jiang W, Jin Z, Zhou F, Cui J, Wang L, Wang L . High co-expression of Sp1 and HER-2 is correlated with poor prognosis of gastric cancer patients. Surg Oncol. 2015; 24(3):220-5. DOI: 10.1016/j.suronc.2015.05.004. View