Endogenous Opioid Function and Responses to Morphine: The Moderating Effects of Anger Expressiveness

Overview

Journal J Pain

Specialties Neurology
Psychiatry

Date 2017 Apr 3

PMID 28365372

Citations 3

Authors

John W Burns

Stephen Bruehl

Christopher R France

Erik Schuster

Daria Orlowska

Melissa Chont

Rajnish K Gupta

Asokumar Buvanendran

Affiliations

Soon will be listed here.

Abstract

Perspective: We sought to identify optimal candidates for opioid pain management. Low back pain patients who express anger and also have deficient endogenous opioid function may be poor candidates for opioid therapy. In contrast, low back patients who tend not to express anger and who also have deficient endogenous opioid function may make optimal candidates for opioid therapy.

Citing Articles

Negative Affect-Related Factors Have the Strongest Association with Prescription Opioid Misuse in a Cross-Sectional Cohort of Patients with Chronic Pain.

Gilam G, Sturgeon J, You D, Wasan A, Darnall B, Mackey S Pain Med. 2019; 21(2):e127-e138.

PMID: 31617916 PMC: 7049262. DOI: 10.1093/pm/pnz249.

Self-reported cumulative medical opioid exposure and subjective responses on first use of opioids predict analgesic and subjective responses to placebo-controlled opioid administration.

Bruehl S, Stone A, Palmer C, Edwards D, Buvanendran A, Gupta R Reg Anesth Pain Med. 2019; 44(1):92-99.

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The association between endogenous opioid function and morphine responsiveness: a moderating role for endocannabinoids.

Bruehl S, Burns J, Morgan A, Koltyn K, Gupta R, Buvanendran A Pain. 2018; 160(3):676-687.

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