The Scavenging Capacity of DMBT1 is Impaired by Germline Deletions

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 2017 Apr 2

PMID 28364129

Citations 5

Authors

Floris J Bikker

Caroline End

Antoon J M Ligtenberg

Stephanie Blaich

Stefan Lyer

Marcus Renner

Rainer Wittig

Kamran Nazmi

Arie van Nieuw Amerongen

Annemarie Poustka

Enno C I Veerman

Jan Mollenhauer

Affiliations

Soon will be listed here.

Abstract

The Scavenger Receptor Cysteine-Rich (SRCR) proteins are an archaic group of proteins characterized by the presence of multiple SRCR domains. They are membrane-bound or secreted proteins, which are generally related to host defense systems in animals. Deleted in Malignant Brain Tumors 1 (DMBT1) is a SRCR protein which is secreted in mucosal fluids and involved in host defense by pathogen binding by its SRCR domains. Genetic polymorphism within DMBT1 leads to DMBT1-alleles giving rise to polypeptides with interindividually different numbers of SRCR domains, ranging from 8 SRCR domains (encoded by 6 kb DMBT1 variant) to 13 SRCR domains (encoded by the 8 kb DMBT1 variant). In the present study, we have investigated whether reduction from 13 to 8 amino-terminal SRCR domains leads to reduction of bacterial binding. The 6 kb variant bound ~20-45% less bacteria compared to the 8 kb variant. These results support the hypothesis that genetic variation in DMBT1 may influence microbial defense.

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