The Effect of Sertraline on the Quality of Life for Children and Adolescents with Anxiety Disorder
Overview
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Introduction: In this study, we aimed to determine the changes in quality of life of children/adolescents with anxiety disorders during six months of sertraline treatment, to investigate parent-child/adolescent concordance in perception of quality of life and to examine the effect of treatment on children/adolescents.
Methods: In this study, 30 patients with anxiety disorders according to criteria specified in Diagnostic and Statistical Manual of Mental Disorders, 4. Edition (DSM-IV) were assigned to sertraline treatment. The patients were evaluated using the Pediatric Quality of Life Inventory (PedsQL), State-Trait Anxiety Inventory for Children, Clinical Global Impression Scale (CGI) and the Children's Global Assessment Scale (CGAS) at 0th, 2 and 6 months.
Results: PedsQL total scores increased significantly with the treatment in children and adolescents (p<.001), however, no differences were observed in parent proxy report (p=.326). The mean CGAS score was 59.85±7.73 at the beginning of treatment and 73.70±7.01 at the end of treatment (p<.001). The average CGI score decreased from 4.68±.96 to 2.27±.84.
Conclusion: It was observed that perception of quality of life in children and adolescents with anxiety disorders increased with the treatment.
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PMID: 30110079 PMC: 9881690. DOI: 10.1590/1516-3180.2018.0145240418.
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PMID: 29101599 DOI: 10.1007/s11011-017-0127-9.