A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes

Overview

Journal J Genet Couns

Publisher Wiley

Specialty Genetics

Date 2017 Mar 31

PMID 28357779

Citations 22

Authors

Sarah Scollon

Amanda Knoth Anglin

Martha Thomas

Joyce T Turner

Kami Wolfe Schneider

Affiliations

Soon will be listed here.

Abstract

An understanding of the role of inherited cancer predisposition syndromes in pediatric tumor diagnoses continues to develop as more information is learned through the application of genomic technology. Identifying patients and their relatives at an increased risk for developing cancer is an important step in the care of this patient population. The purpose of this review is to highlight various tumor types that arise in the pediatric population and the cancer predisposition syndromes associated with those tumors. The review serves as a guide for recognizing genes and conditions to consider when a pediatric cancer referral presents to the genetics clinic.

Citing Articles

Pediatric cancer predisposition syndromes involving non-central nervous system solid pediatric tumors: a review on their manifestations with a focus on histopathology.

Schurink B, Reyes-Mugica M, de Krijger R Virchows Arch. 2025; 486(1):3-21.

PMID: 39847050 PMC: 11782299. DOI: 10.1007/s00428-025-04029-1.

Germline Variants in Cancer Predisposition Genes in Pediatric Patients with Central Nervous System Tumors.

Jovanovic A, Tosic N, Marjanovic I, Komazec J, Zukic B, Nikitovic M Int J Mol Sci. 2023; 24(24).

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Simultaneous Occurrence of Multiple Neoplasms in Children with Cancer Predisposition Syndromes: Collaborating with Abnormal Genes.

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Genomics-Driven Precision Medicine in Pediatric Solid Tumors.

Suthapot P, Chiangjong W, Chaiyawat P, Choochuen P, Pruksakorn D, Sangkhathat S Cancers (Basel). 2023; 15(5).

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Splicing-Disrupting Mutations in Inherited Predisposition to Solid Pediatric Cancer.

Alba-Pavon P, Alana L, Astigarraga I, Villate O Cancers (Basel). 2022; 14(23).

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