Uterus Transplantation and Beyond

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2017 Mar 31

PMID 28357688

Citations 17

Authors

Mats Brannstrom

Affiliations

Soon will be listed here.

Abstract

Uterus transplantation is today the only available treatment for absolute uterine factor infertility which is caused by either congenital/surgical uterine absence or that a present uterus is non-functioning. Structured animal-based research, from rodents to nonhuman primates, was the scientific basis for a successful introduction of uterus transplantation as a clinical procedure. The patient groups for uterus transplantation, the preclinical research and data from the published human cases will be covered herein. During recent years the concept of bioengineering of organs and tissues has emerged. Creation of a bioengineered uterus is in the initial research state, with experiments performed in rodents. The research that has been performed to create a bioengineered uterus will be summarized. In conclusion, uterus transplantation is now a clinical experimental procedure for treatment of uterine factor infertility. In parallel to the establishment of this combined assisted reproduction technique and transplantation procedure as a routine clinical procedure, we predict that uterus bioengineering will develop further towards introduction within the human setting, but that this process will take several years.

Citing Articles

Uterus transplantation: A bibliometric review of six-decade study from 1960 to 2024.

Akbari R, Ghaemi M, Panahi Z Acta Obstet Gynecol Scand. 2024; 104(3):437-451.

PMID: 39579060 PMC: 11871124. DOI: 10.1111/aogs.14977.

Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration.

Chen S, Li J, Zheng L, Huang J, Wang M Exploration (Beijing). 2024; 4(5):20230141.

PMID: 39439492 PMC: 11491300. DOI: 10.1002/EXP.20230141.

A new bicornuate model of rat uterus transplantation.

Polenz D, Sauer I, Martin F, Reutzel-Selke A, Ashraf M, Schirmeier A Acta Obstet Gynecol Scand. 2024; 104(3):452-460.

PMID: 38693698 PMC: 11871102. DOI: 10.1111/aogs.14857.

The reproductive potential of uterus transplantation: future prospects.

Gullo G, Etrusco A, Fabio M, Cucinella G, Rossi C, Billone V Acta Biomed. 2022; 93(2):e2022138.

PMID: 35546000 PMC: 9171877. DOI: 10.23750/abm.v93i2.12868.

Whole-organ decellularization of the human uterus and in vivo application of the bio-scaffolds in animal models.

Daryabari S, Fendereski K, Ghorbani F, Dehnavi M, Shafikhani Y, Omranipour A J Assist Reprod Genet. 2022; 39(6):1237-1247.

PMID: 35513746 PMC: 9174384. DOI: 10.1007/s10815-022-02492-2.

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