Wanted , Dead or Alive

Overview

Journal Microb Cell

Specialty Microbiology

Date 2017 Mar 31

PMID 28357297

Citations 5

Authors

Fatimata Sow

Mary Nyonda

Anne-Lise Bienvenu

Stephane Picot

Affiliations

Soon will be listed here.

Abstract

Mechanisms of cell death in unicellular parasites have been subjects of debate for the last decade, with studies demonstrating evidence of apoptosis or non-apoptosis like mechanisms, including necrosis, and autophagy. Recent clarifications on the definition of regulated or accidental cell death by The Nomenclature Committee on Cell Death provides an opportunity to reanalyze some data, re-evaluate conclusions in the light of parasite diversity, and to propose alternative arguments in the context of malaria drug resistance, considering lack of really new drugs in the pipeline. Deciphering the mechanisms of death may help in detection of new drug targets and the design of innovative drugs. However, classifications have been evolving rapidly since initial description of "programmed cell death", leading to some uncertainty as to whether cell death is accidental or regulated.

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