Melittin Inhibits the Invasion of MCF-7 Cells by Downregulating CD147 and MMP-9 Expression

Overview

Journal Oncol Lett

Specialty Oncology

Date 2017 Mar 31

PMID 28356935

Citations 8

Authors

Jianjun Wang

Fengyu Li

Jiang Tan

Xuewei Peng

Lili Sun

Ping Wang

Shengnan Jia

Qingmiao Yu

Hongliang Huo

Hongyan Zhao

Affiliations

Soon will be listed here.

Abstract

Tumor invasion and metastasis are the critical steps in determining the aggressive phenotype of human cancers. Melittin, a major component of bee venom, has been reported to induce apoptosis in several cancer cells. However, the mechanisms of melittin involvement in cancer invasion and metastasis remain unclear. Our previous study indicated that melittin inhibits cyclophilin A (CypA), a ubiquitously distributed peptidylprolyl isomerase, in macrophage cells. In the present study, the Transwell assay results showed that melittin may downregulate the invasion level of MCF-7 cells in a dose-dependent manner. Additionally, it was also found, using flow cytometry and reverse transcription-polymerase chain reaction, that melittin decreased the expression of cluster of differentiation (CD)147 and matrix metallopeptidase-9 (MMP-9), whereas CypA upregulated the expression of CD147 and MMP-9. Overall, the present study indicated that melittin decreased the invasion level of MCF-7 cells by downregulating CD147 and MMP-9 by inhibiting CypA expression. The results of the present study provide an evidence for melittin in anticancer therapy and mechanisms.

Citing Articles

Melittin Inhibits Colorectal Cancer Growth and Metastasis by Ac-Tivating the Mitochondrial Apoptotic Pathway and Suppressing Epithelial-Mesenchymal Transition and Angiogenesis.

Wang K, Tao L, Zhu M, Yu X, Lu Y, Yuan B Int J Mol Sci. 2024; 25(21).

PMID: 39519238 PMC: 11546240. DOI: 10.3390/ijms252111686.

Cyclophilin A: promising target in cancer therapy.

Jin S, Zhang M, Qiao X Cancer Biol Ther. 2024; 25(1):2425127.

PMID: 39513594 PMC: 11552246. DOI: 10.1080/15384047.2024.2425127.

Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549).

Sengul F, Vatansev H, Ozturk B Mol Biol Rep. 2023; 51(1):2.

PMID: 38057592 DOI: 10.1007/s11033-023-09002-2.

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers.

Pandey P, Khan F, Khan M, Kumar R, Upadhyay T Nutrients. 2023; 15(14).

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Can Bee Venom Be Used as Anticancer Agent in Modern Medicine?.

Malek A, Strzemski M, Kurzepa J, Kurzepa J Cancers (Basel). 2023; 15(14).

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