BIOPHYSICAL PROPERTIES OF SUBTHRESHOLD RESONANCE OSCILLATIONS AND SUBTHRESHOLD MEMBRANE OSCILLATIONS IN NEURONS

Overview

Journal J Biol Syst

Specialty Biology

Date 2017 Mar 31

PMID 28356608

Citations 1

Authors

Babak V-Ghaffari

M Kouhnavard

T Kitajima

Affiliations

Soon will be listed here.

Abstract

Subthreshold-level activities in neurons play a crucial role in neuronal oscillations. These small-amplitude oscillations have been suggested to be involved in synaptic plasticity and in determining the frequency of network oscillations. Subthreshold membrane oscillations (STOs) and subthreshold resonance oscillations (SROs) are the main constituents of subthreshold-level activities in neurons. In this study, a general theoretical framework for analyzing the mechanisms underlying STOs and SROs in neurons is presented. Results showed that the resting membrane potential and the hyperpolarization-activated potassium channel (-channel) affect the subthreshold-level activities in stellate cells. The contribution of -channel on resonance is attributed to its large time constant, which produces the time lag between and the membrane potential. Conversely, the persistent sodium channels (Nap-channels) only play an amplifying role in these neurons.

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