Effects of Osteopontin-enriched Formula on Lymphocyte Subsets in the First 6 Months of Life: a Randomized Controlled Trial

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2017 Mar 30

PMID 28355198

Citations 18

Authors

Christina E West

Anne Staudt Kvistgaard

Janet M Peerson

Sharon M Donovan

Yong-Mei Peng

Bo Lonnerdal

Affiliations

Soon will be listed here.

Abstract

BackgroundHuman milk is rich in osteopontin (OPN), which has immunomodulatory functions.MethodsIn a randomized controlled trial, standard formula (SF) and the same formula with 65 mg of OPN/L (F65) or 130 mg of OPN/L (F130), representing ~50 and 100% of the OPN concentration in human milk, were compared. We examined frequencies and composition of peripheral blood immune cells by four-color immunoflow cytometry of formula-fed infants at ages 1, 4, and 6 months, and compared them with a breastfed (BF) reference group.ResultsThe F130 group had increased T-cell proportions compared with the SF (P=0.036, average effect size 0.51) and F65 groups (P=0.008, average effect size 0.65). Compared with the BF group, the monocyte proportions were increased in the F65 (P=0.001, average effect size 0.59) and F130 (P=0.006, average effect size 0.50) groups, but were comparable among the formula groups.ConclusionOPN in an infant formula at a concentration close to that of human milk increased the proportion of circulating T cells compared with both SF and formula with added OPN at ~50% of the concentration in human milk. This suggests that OPN may favorably influence immune ontogeny in infancy and that the effects appear to be dose-dependent.

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