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Semaphorin 3F Expression is Reduced in Pregnancy Complicated by Preeclampsia. An Observational Clinical Study

Overview
Journal PLoS One
Date 2017 Mar 29
PMID 28350837
Citations 6
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Abstract

Background And Objective: Preeclampsia is a systemic disorder, affecting 2-10% of pregnancies, characterized by a deregulated pro- and anti-angiogenic balance. Semaphorin 3F is an angiogenesis inhibitor. We aimed to investigate whether semaphorin 3F expression is modulated in preeclampsia.

Design, Setting, Participants, And Measurements: We performed two observational single center cohort studies between March 2013 and August 2014. In the first we enrolled 110 consecutive women, undergoing an elective cesarean section; in the second we included 150 consecutive women undergoing amniocentesis for routine clinical indications at 16-18 week of gestation. Semaphorin 3F concentration was evaluated in maternal peripheral blood, venous umbilical blood and amniotic fluid, along with its placenta protein expression at the time of delivery in the first study group and in the amniotic fluid at 16-18 weeks of gestation in the second study group.

Results: In the first study 19 patients presented at delivery with preeclampsia. Semaphorin 3F placenta tissue expression was significantly reduced in preeclampsia. In addition, semaphorin 3F level at delivery was significantly lower in serum, amniotic fluid and venous umbilical blood of preeclamptic patients compared with normal pregnant women. In the prospective cohort study 14 women developed preeclampsia. In this setting, semaphorin 3F amniotic level at 16-18 weeks of gestation was reduced in women who subsequently developed preeclampsia compared to women with a normal pregnancy. ROC curve analysis showed that semaphorin 3F amniotic levels could identify women at higher risk of preeclampsia.

Conclusions: Semaphorin 3F might represent a predictive biomarker of preeclampsia.

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References
1.
Bielenberg D, Hida Y, Shimizu A, Kaipainen A, Kreuter M, Kim C . Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. J Clin Invest. 2004; 114(9):1260-71. PMC: 524226. DOI: 10.1172/JCI21378. View

2.
Burton G, Jauniaux E . Placental oxidative stress: from miscarriage to preeclampsia. J Soc Gynecol Investig. 2004; 11(6):342-52. DOI: 10.1016/j.jsgi.2004.03.003. View

3.
Roche J, Boldog F, Robinson M, Robinson L, Varella-Garcia M, SWANTON M . Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. Oncogene. 1996; 12(6):1289-97. View

4.
Wyatt S, Kraus F, Roh C, Elchalal U, Nelson D, Sadovsky Y . The correlation between sampling site and gene expression in the term human placenta. Placenta. 2005; 26(5):372-9. DOI: 10.1016/j.placenta.2004.07.003. View

5.
Coma S, Shimizu A, Klagsbrun M . Hypoxia induces tumor and endothelial cell migration in a semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor neuropilin 2. Cell Adh Migr. 2011; 5(3):266-75. PMC: 3210211. DOI: 10.4161/cam.5.3.16294. View