Subclinical Hypothyroidism and the Risk of Hypercholesterolemia

Overview

Journal J Family Med Prim Care

Specialty Public Health

Date 2017 Mar 29

PMID 28348996

Citations 8

Authors

Indhu Aynipully Jayasingh

Paul Puthuran

Affiliations

Soon will be listed here.

Abstract

Introduction: Subclinical hypothyroidism (SCH) is a condition wherein there are small elevations in thyroid stimulating hormone (TSH), yet normal circulating levels of free thyroid hormones (FT4). Alterations in thyroid function result in changes in composition and transport of lipoproteins.

Methods: The study was undertaken in the outpatient department of Lourdes hospital, Ernakulam. 110 patients between 40-69 years were studied, of which 60 were identified to have SCH based on cross-sectional survey, 50 patients were randomly selected to represent the EU group. Data based on interview, clinical examination, thyroid function, lipid profiles. Student's t, chi-square tests used for computation of values.

Results: SCH were seen in females (66.66%) and in the age group of 40-49 years (61.66%). Mean cholesterol values were elevated in the subclinical hypothyroid group and in relation to age (60-69) and gender. Statistical analysis showed significant difference in total cholesterol(TC) (<0.005) and triglycerides (<0.05) in relation to age (40-49 yrs.) between two groups. Based on TSH, group A 5-7.49Mu/L and group B 7.5-10Mu/L were compared to the euthyroid group N<5Mu/L. Mean cholesterol values were raised in both subgroups. Statistically significant difference seen (<0.0005) in cholesterol values between the subclinical hypothyroid group B and the euthyroid group N.

Conclusions: SCH appears to be associated with increased mean cholesterol levels in females and of age > 60 years. The TC values were elevated in both subgroups of patients with SCH (A and B) based on TSH values.

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References

Col N, Surks M, Daniels G . Subclinical thyroid disease: clinical applications. JAMA. 2004; 291(2):239-43. DOI: 10.1001/jama.291.2.239. View

Muls E, Rosseneu M, Blaton V, Lesaffre E, Lamberigts G, DE MOOR P . Serum lipids and apolipoproteins A-I, A-II and B in primary hypothyroidism before and during treatment. Eur J Clin Invest. 1984; 14(1):12-5. DOI: 10.1111/j.1365-2362.1984.tb00697.x. View

Tanis B, Westendorp G, Smelt H . Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies. Clin Endocrinol (Oxf). 1996; 44(6):643-9. DOI: 10.1046/j.1365-2265.1996.739560.x. View

Bandyopadhyay S, Basu A, Pal S, Roy P, Chakrabarti S, Pathak H . A study on dyslipidaemia in subclinical hypothyroidism. J Indian Med Assoc. 2007; 104(11):622-4, 626. View

Evered D, Ormston B, Smith P, Hall R, Bird T . Grades of hypothyroidism. Br Med J. 1973; 1(5854):657-62. PMC: 1588654. DOI: 10.1136/bmj.1.5854.657. View

Valdemarsson S, Hansson P, HEDNER P, Nilsson-Ehle P . Relations between thyroid function, hepatic and lipoprotein lipase activities, and plasma lipoprotein concentrations. Acta Endocrinol (Copenh). 1983; 104(1):50-6. DOI: 10.1530/acta.0.1040050. View

Cooper D . Subclinical thyroid disease: a clinician's perspective. Ann Intern Med. 1998; 129(2):135-8. DOI: 10.7326/0003-4819-129-2-199807150-00016. View

Hak A, Pols H, Visser T, Drexhage H, Hofman A, Witteman J . Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med. 2000; 132(4):270-8. DOI: 10.7326/0003-4819-132-4-200002150-00004. View

Canaris G, Manowitz N, Mayor G, Ridgway E . The Colorado thyroid disease prevalence study. Arch Intern Med. 2000; 160(4):526-34. DOI: 10.1001/archinte.160.4.526. View

10.

Danese M, Ladenson P, Meinert C, Powe N . Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J Clin Endocrinol Metab. 2000; 85(9):2993-3001. DOI: 10.1210/jcem.85.9.6841. View

11.

Hueston W, Pearson W . Subclinical hypothyroidism and the risk of hypercholesterolemia. Ann Fam Med. 2004; 2(4):351-5. PMC: 1466694. DOI: 10.1370/afm.79. View

12.

Ladenson P, Singer P, Ain K, BAGCHI N, Bigos S, Levy E . American Thyroid Association guidelines for detection of thyroid dysfunction. Arch Intern Med. 2000; 160(11):1573-5. DOI: 10.1001/archinte.160.11.1573. View

13.

Surks M, Ortiz E, Daniels G, Sawin C, Col N, Cobin R . Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291(2):228-38. DOI: 10.1001/jama.291.2.228. View

14.

Samuels M . Subclinical thyroid disease in the elderly. Thyroid. 1998; 8(9):803-13. DOI: 10.1089/thy.1998.8.803. View

15.

Bastenie P, Vanhaelst L, BONNYNS M, Neve P, STAQUET M . Preclinical hypothyroidism: a risk factor for coronary heart-disease. Lancet. 1971; 1(7692):203-4. DOI: 10.1016/s0140-6736(71)90947-0. View

16.

Kahaly G . Cardiovascular and atherogenic aspects of subclinical hypothyroidism. Thyroid. 2000; 10(8):665-79. DOI: 10.1089/10507250050137743. View

17.

Luboshitzky R, Aviv A, Herer P, Lavie L . Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Thyroid. 2002; 12(5):421-5. DOI: 10.1089/105072502760043512. View

18.

Pearce E . Hypothyroidism and dyslipidemia: modern concepts and approaches. Curr Cardiol Rep. 2004; 6(6):451-6. DOI: 10.1007/s11886-004-0054-3. View

19.

Vanderpump M, Tunbridge W, French J, Appleton D, Bates D, Clark F . The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995; 43(1):55-68. DOI: 10.1111/j.1365-2265.1995.tb01894.x. View

20.

LINDEMAN R, Schade D, Larue A, Romero L, Liang H, Baumgartner R . Subclinical hypothyroidism in a biethnic, urban community. J Am Geriatr Soc. 1999; 47(6):703-9. DOI: 10.1111/j.1532-5415.1999.tb01593.x. View