Components of Goutengsan in Rat Plasma by Microdialysis Sampling and Its Protection on A-Induced PC12 Cells Injury

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2017 Mar 29

PMID 28348625

Citations 2

Authors

Hou-Cai Huang

Chun-Fei Wang

Jun-Fei Gu

Juan Chen

Xue-Feng Hou

Rong-Ling Zhong

Zhi Xia

Di Zhao

Nan Yang

Jing Wang

Xiao-Bin Tan

Xiao-Bin Jia

Liu-Qing DI

Zi-Bo Dong

Liang Feng

Affiliations

Soon will be listed here.

Abstract

Goutengsan, a Chinese herbal formula, potential protection on Alzheimer's disease (AD) has been less reported. In current study, we investigated the protection of Goutengsan on A-induced pheochromocytoma-derived cells (PC12). Furthermore, the components from Goutengsan in rat plasma were identified by microdialysis (MD) for sampling. Meanwhile, the protection of components identified was also verified. At last, we found that Goutengsan has a potential protective effect on A-induced PC12 cells via reducing cells damage and increasing cells vitality as well as six components (pachymic acid, liquiritin, rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxeine) which may be effective components. This study helps to understand the treatment of Goutengsan for AD and would facilitate the clinical and further studies for this formula.

Citing Articles

The beneficial pharmacological effects of in neurodegenerative diseases: focus on alkaloids.

Chen L, Liu Y, Xie J Front Pharmacol. 2024; 15:1436481.

PMID: 39170707 PMC: 11336414. DOI: 10.3389/fphar.2024.1436481.

Identification of in the Potential Treatment of Alzheimer's Disease by Integrating Virtual Screening and In Vitro Validation.

Jiang S, Borjigin G, Sun J, Li Q, Wang Q, Mu Y Int J Mol Sci. 2023; 24(20).

PMID: 37895137 PMC: 10607254. DOI: 10.3390/ijms242015457.

References

Zhang Y, Lin C, Zhang L, Cui Y, Gu Y, Guo J . Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial. PLoS One. 2015; 10(6):e0130353. PMC: 4468068. DOI: 10.1371/journal.pone.0130353. View

Rushworth J, Hooper N . Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. Int J Alzheimers Dis. 2011; 2011:603052. PMC: 3014710. DOI: 10.4061/2011/603052. View

Liu P, Kong M, Liu S, Chen G, Wang P . Effect of reinforcing kidney-essence, removing phlegm, and promoting mental therapy on treating Alzheimer's disease. J Tradit Chin Med. 2013; 33(4):449-54. DOI: 10.1016/s0254-6272(13)60147-8. View

Meng P, Yoshida H, Tanji K, Matsumiya T, Xing F, Hayakari R . Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells. Neurosci Res. 2014; 94:1-9. DOI: 10.1016/j.neures.2014.12.003. View

Carson B, McCormack W, Conway C, Cooke J, Saunders J, OConnor W . An in vivo microdialysis characterization of the transient changes in the interstitial dialysate concentration of metabolites and cytokines in human skeletal muscle in response to insertion of a microdialysis probe. Cytokine. 2014; 71(2):327-33. DOI: 10.1016/j.cyto.2014.10.022. View

Tariot P, Cummings J, Katz I, Mintzer J, Perdomo C, Schwam E . A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting. J Am Geriatr Soc. 2002; 49(12):1590-9. View

Qian M, Liu J, Yao J, Wang W, Yang J, Wei L . Caspase-8 Mediates Amyloid-β-induced Apoptosis in Differentiated PC12 Cells. J Mol Neurosci. 2015; 56(2):491-9. DOI: 10.1007/s12031-015-0498-5. View

Zhang Q, Wu D, Wu J, Ou Y, Mu C, Han B . Improved blood-brain barrier distribution: effect of borneol on the brain pharmacokinetics of kaempferol in rats by in vivo microdialysis sampling. J Ethnopharmacol. 2015; 162:270-7. DOI: 10.1016/j.jep.2015.01.003. View

Watanabe H, Zhao Q, Matsumoto K, Tohda M, Murakami Y, Zhang S . Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine. Pharmacol Biochem Behav. 2003; 75(3):635-43. DOI: 10.1016/s0091-3057(03)00109-6. View

10.

Matsumoto K, Zhao Q, Niu Y, Fujiwara H, Tanaka K, Sasaki-Hamada S . Kampo formulations, chotosan, and yokukansan, for dementia therapy: existing clinical and preclinical evidence. J Pharmacol Sci. 2013; 122(4):257-69. DOI: 10.1254/jphs.13r03cr. View

11.

Larson M, Lesne S . Soluble Aβ oligomer production and toxicity. J Neurochem. 2011; 120 Suppl 1:125-139. PMC: 3254782. DOI: 10.1111/j.1471-4159.2011.07478.x. View

12.

Zhang S, Xue Z . Effect of Western medicine therapy assisted by Ginkgo biloba tablet on vascular cognitive impairment of none dementia. Asian Pac J Trop Med. 2012; 5(8):661-4. DOI: 10.1016/S1995-7645(12)60135-7. View

13.

Bi M, Tong S, Zhang Z, Ma Q, Zhang S, Luo Z . Changes in cerebral glucose metabolism in patients with mild-to-moderate Alzheimer's disease: a pilot study with the Chinese herbal medicine fuzhisan. Neurosci Lett. 2011; 501(1):35-40. DOI: 10.1016/j.neulet.2011.06.036. View

14.

Hefti F, Goure W, Jerecic J, Iverson K, Walicke P, Krafft G . The case for soluble Aβ oligomers as a drug target in Alzheimer's disease. Trends Pharmacol Sci. 2013; 34(5):261-6. DOI: 10.1016/j.tips.2013.03.002. View

15.

Hsu W, Ku Y, Zanto T, Gazzaley A . Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis. Neurobiol Aging. 2015; 36(8):2348-59. PMC: 4496249. DOI: 10.1016/j.neurobiolaging.2015.04.016. View

16.

Saylor R, Lunte S . A review of microdialysis coupled to microchip electrophoresis for monitoring biological events. J Chromatogr A. 2015; 1382:48-64. PMC: 4403801. DOI: 10.1016/j.chroma.2014.12.086. View

17.

Diczfalusy E, Andersson M, Wardell K . A diffusion tensor-based finite element model of microdialysis in the deep brain. Comput Methods Biomech Biomed Engin. 2013; 18(2):201-12. DOI: 10.1080/10255842.2013.789103. View

18.

Tamayev R, Akpan N, Arancio O, Troy C, DAdamio L . Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection. Mol Neurodegener. 2012; 7:60. PMC: 3543220. DOI: 10.1186/1750-1326-7-60. View

19.

Nakajima A, Aoyama Y, Shin E, Nam Y, Kim H, Nagai T . Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD). Behav Brain Res. 2015; 289:69-77. DOI: 10.1016/j.bbr.2015.04.028. View

20.

Wurstle M, Laussmann M, Rehm M . The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome. Exp Cell Res. 2012; 318(11):1213-20. DOI: 10.1016/j.yexcr.2012.02.013. View