Bacterial Bloodstream Infections in the Allogeneic Hematopoietic Cell Transplant Patient: New Considerations for a Persistent Nemesis

Overview

Journal Bone Marrow Transplant

Specialty General Surgery

Date 2017 Mar 28

PMID 28346417

Citations 34

Authors

C E Dandoy

M I Ardura

G A Papanicolaou

J J Auletta

Affiliations

Soon will be listed here.

Abstract

Bacterial bloodstream infections (BSI) cause significant transplant-related morbidity and mortality following allogeneic hematopoietic cell transplantation (allo-HCT). This manuscript reviews the risk factors for and the bacterial pathogens causing BSIs in allo-HCT recipients in the contemporary transplant period. In addition, it offers insight into emerging resistant pathogens and reviews clinical management considerations to treat and strategies to prevent BSIs in allo-HCT patients.

Citing Articles

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Outcomes within 100 days of hematopoietic cell transplantation in pediatric patients: insights from an intensive care unit in Colombia.

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Risk factors of bloodstream infection after allogeneic hematopoietic cell transplantation in children/adolescent and young adults.

Sajiki D, Muramatsu H, Wakamatsu M, Yamashita D, Maemura R, Tsumura Y PLoS One. 2024; 19(8):e0308395.

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References

Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J . Guidelines for preventing infectious complications among hematopoietic cell transplant recipients: a global perspective. Preface. Bone Marrow Transplant. 2009; 44(8):453-5. DOI: 10.1038/bmt.2009.254. View

Schiffer C, Mangu P, Wade J, Camp-Sorrell D, Cope D, El-Rayes B . Central venous catheter care for the patient with cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2013; 31(10):1357-70. DOI: 10.1200/JCO.2012.45.5733. View

Ballen K, Ahn K, Chen M, Abdel-Azim H, Ahmed I, Aljurf M . Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016; 22(9):1636-1645. PMC: 5008458. DOI: 10.1016/j.bbmt.2016.06.012. View

Foster T, Hook M . Surface protein adhesins of Staphylococcus aureus. Trends Microbiol. 1999; 6(12):484-8. DOI: 10.1016/s0966-842x(98)01400-0. View

Mitchell A, Derrington P, Turner P, Hunt L, Oakhill A, Marks D . Gram-negative bacteraemia (GNB) after 428 unrelated donor bone marrow transplants (UD-BMT): risk factors, prophylaxis, therapy and outcome. Bone Marrow Transplant. 2003; 33(3):303-10. DOI: 10.1038/sj.bmt.1704338. View

Lalla R, Bowen J, Barasch A, Elting L, Epstein J, Keefe D . MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014; 120(10):1453-61. PMC: 4164022. DOI: 10.1002/cncr.28592. View

Freifeld A, Bow E, Sepkowitz K, Boeckh M, Ito J, Mullen C . Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis. 2011; 52(4):e56-93. DOI: 10.1093/cid/cir073. View

Freeman J, Elinder-Camburn A, McClymont C, Anderson D, Bilkey M, Williamson D . Central line-associated bloodstream infections in adult hematology patients with febrile neutropenia: an evaluation of surveillance definitions using differential time to blood culture positivity. Infect Control Hosp Epidemiol. 2012; 34(1):89-92. PMC: 3628695. DOI: 10.1086/668431. View

Epstein L, See I, Edwards J, Magill S, Thompson N . Mucosal Barrier Injury Laboratory-Confirmed Bloodstream Infections (MBI-LCBI): Descriptive Analysis of Data Reported to National Healthcare Safety Network (NHSN), 2013. Infect Control Hosp Epidemiol. 2015; 37(1):2-7. PMC: 6557152. DOI: 10.1017/ice.2015.245. View

10.

Worth L, Slavin M, Heath S, Szer J, Grigg A . Ethanol versus heparin locks for the prevention of central venous catheter-associated bloodstream infections: a randomized trial in adult haematology patients with Hickman devices. J Hosp Infect. 2014; 88(1):48-51. DOI: 10.1016/j.jhin.2014.06.007. View

11.

Cecinati V, Brescia L, Tagliaferri L, Giordano P, Esposito S . Catheter-related infections in pediatric patients with cancer. Eur J Clin Microbiol Infect Dis. 2012; 31(11):2869-77. DOI: 10.1007/s10096-012-1652-4. View

12.

Busca A, Cavecchia I, Locatelli F, DArdia S, De Rosa F, Marmont F . Blood stream infections after allogeneic stem cell transplantation: a single-center experience with the use of levofloxacin prophylaxis. Transpl Infect Dis. 2011; 14(1):40-8. DOI: 10.1111/j.1399-3062.2011.00650.x. View

13.

Price J, Golubchik T, Cole K, Wilson D, Crook D, Thwaites G . Whole-genome sequencing shows that patient-to-patient transmission rarely accounts for acquisition of Staphylococcus aureus in an intensive care unit. Clin Infect Dis. 2013; 58(5):609-18. PMC: 3922217. DOI: 10.1093/cid/cit807. View

14.

Torres D, Gonzalez M, Loera A, Aguilera M, Relyea G, Aristizabal P . The Centers for Disease Control and Prevention definition of mucosal barrier injury-associated bloodstream infection improves accurate detection of preventable bacteremia rates at a pediatric cancer center in a low- to middle-income country. Am J Infect Control. 2016; 44(4):432-7. PMC: 4818654. DOI: 10.1016/j.ajic.2015.11.007. View

15.

Zimlichman E, Henderson D, Tamir O, Franz C, Song P, Yamin C . Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med. 2013; 173(22):2039-46. DOI: 10.1001/jamainternmed.2013.9763. View

16.

Ray A, Hoyen C, Taub T, Eckstein E, Donskey C . Nosocomial transmission of vancomycin-resistant enterococci from surfaces. JAMA. 2002; 287(11):1400-1. DOI: 10.1001/jama.287.11.1400. View

17.

Bock A, Cao Q, Ferrieri P, Young J, Weisdorf D . Bacteremia in blood or marrow transplantation patients: clinical risk factors for infection and emerging antibiotic resistance. Biol Blood Marrow Transplant. 2012; 19(1):102-8. DOI: 10.1016/j.bbmt.2012.08.016. View

18.

Smith K, Robertson D, Lappin D, Ramage G . Commercial mouthwashes are ineffective against oral MRSA biofilms. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 115(5):624-9. DOI: 10.1016/j.oooo.2012.12.014. View

19.

Adams D, Eberly M, Goudie A, Nylund C . Rising Vancomycin-Resistant Enterococcus Infections in Hospitalized Children in the United States. Hosp Pediatr. 2016; 6(7):404-11. DOI: 10.1542/hpeds.2015-0196. View

20.

Rinke M, Bundy D, Chen A, Milstone A, Colantuoni E, Pehar M . Central line maintenance bundles and CLABSIs in ambulatory oncology patients. Pediatrics. 2013; 132(5):e1403-12. PMC: 3813391. DOI: 10.1542/peds.2013-0302. View