Comparison of Physicochemical Properties of Suppositories Containing Starch Hydrolysates

Overview

Journal Saudi Pharm J

Specialty Pharmacy

Date 2017 Mar 28

PMID 28344490

Citations 2

Authors

Piotr Belniak

Katarzyna Swiader

Michal Szumilo

Aleksandra Hyla

Ewa Poleszak

Affiliations

Soon will be listed here.

Abstract

The purpose of this work was to determine the effect of starch hydrolysates (SH) on the physicochemical properties of suppositories. The study was conducted with suppositories with acetaminophen (AAP) a typical antipyretic analgesic, as model drug on lipophilic (cocoa butter) and hydrophilic base (polyethylene glycol 1500 + 400). The suppositories with and without the addition of SH were examined for physicochemical tests according to European Pharmacopoeia 8th edition (Ph. Eur.): the uniformity of mass of single-dose preparation test, the softening time determination of lipophilic suppositories test, the disintegration of suppositories test, and dissolution test with flow-through apparatus. The results confirm the possibility of using starch hydrolysates as a cheap and safe addition to modify physicochemical properties of suppositories.

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