Distribution of Vitamin B12 R-binder in Carcinomas of the Digestive Tract

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1988 Mar 1

PMID 2834423

Authors

H Kudo

G Ohshio

K Ogawa

Y C Kim

Y Wakatsuki

Y Nakashima

H Yamabe

M Inada

Affiliations

Soon will be listed here.

Abstract

To evaluate whether the increase in serum transcobalamin I, seen in patients with carcinoma, is caused by synthesis of R-binder to tumour cells, the distribution of vitamin B12 R-binder in 125 malignant growths of the digestive tract was studied. Positive staining for R-binder with immunoperoxidase was observed in 85 (70%) carcinomas. Positive staining for R-binder was observed in all four cholangiocarcinomas studied, but was absent in nine hepatocellular carcinomas. These findings suggest that determination of R-binder in liver tumours may be of some value in differentiating hepatocellular carcinomas and cholangiocarcinoma, and that synthesis of R-binder by tumour cells causes an increase in serum transcobalamin I.

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