Cortical Microstructure Compensates for Smaller Bone Size in Young Caribbean Hispanic Versus Non-Hispanic White Men

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2017 Mar 26

PMID 28341899

Citations 3

Authors

M D Walker

A Kepley

K Nishiyama

B Zhou

E Guo

T L Nickolas

Affiliations

Soon will be listed here.

Abstract

Introduction: The purpose of this study was to assess differences in vBMD and microarchitecture in young Caribbean Hispanic (n = 30) and non-Hispanic Caucasian (n = 30) men.

Methods: We measured areal bone mineral density (aBMD) at the spine, total hip (TH), femoral neck (FN), and forearm by dual-energy X-ray absorptiometry (DXA) and bone geometry, mass, microarchitecture, and mechanical competence by high-resolution peripheral quantitative computed tomography (HRpQCT), individual trabecula segmentation (ITS), and finite element analysis (FEA).

Results: Hispanic men were slightly older, shorter, and heavier and had higher BMI compared with white men. aBMD, measured by DXA, did not differ at the spine, TH, or forearm before or after adjustment for age, height, weight, and the interaction of height and weight. At the FN, marginally significant higher BMD in Hispanics prior to adjustment was attenuated and no longer differed after adjustment for covariates. Adjusted HRpQCT indices indicated smaller total and trabecular area at the radius but greater total volumetric density and cortical thickness in Hispanic versus white men. The adjusted difference in cortical density at the radius was of borderline significance. Trabecular and ITS microstructure tended not to differ at the radius. At the tibia, results were similar. Bone size tended to be smaller and covariate-adjusted cortical density and cortical thickness were greater in Hispanic versus white men. Additionally, cortical porosity was lower at the tibia in Hispanic compared to white men. Stiffness and failure load did not differ at either skeletal site by ethnicity.

Conclusion: In conclusion, greater cortical thickness and density as well as lower cortical porosity tend to compensate for smaller bone size in Hispanic men, leading to similar mechanical competence compared with white men.

Citing Articles

Ethnic Differences in Bone Microarchitecture.

Durdin R, Parsons C, Dennison E, Harvey N, Cooper C, Ward K Curr Osteoporos Rep. 2020; 18(6):803-810.

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Current anti-depressant use is associated with cortical bone deficits and reduced physical function in elderly women.

Agarwal S, Germosen C, Kil N, Bucovsky M, Colon I, Williams J Bone. 2020; 140:115552.

PMID: 32730935 PMC: 7502521. DOI: 10.1016/j.bone.2020.115552.

Characterization of trabecular bone microstructure in premenopausal women with distal radius fractures.

Rozental T, Johannesdottir F, Kempland K, Bouxsein M Osteoporos Int. 2017; 29(2):409-419.

PMID: 29101409 DOI: 10.1007/s00198-017-4293-8.

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