Advances in MALDI Imaging Mass Spectrometry of Proteins in Cardiac Tissue, Including the Heart Valve

Overview

Journal Biochim Biophys Acta Proteins Proteom

Publisher Elsevier

Specialties Biochemistry
Biophysics
Molecular Biology

Date 2017 Mar 26

PMID 28341601

Citations 17

Authors

Peggi M Angel

H Scott Baldwin

Danielle Gottlieb Sen

Yan Ru Su

John E Mayer

David Bichell

Richard R Drake

Affiliations

Soon will be listed here.

Abstract

Significant progress has been made for tissue imaging of proteins using matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). These advancements now facilitate mapping of a wide range of proteins, peptides, and post-translational modifications in a wide variety of tissues; however, the use of MALDI IMS to detect proteins from cardiac tissue is limited. This review discusses the most recent advances in protein imaging and demonstrates application to cardiac tissue, including the heart valve. Protein imaging by MALDI IMS allows multiplexed histological mapping of proteins and protein components that are inaccessible by antibodies and should be considered an important tool for basic and clinical cardiovascular research. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann.

Citing Articles

A Proof of Principle 2D Spatial Proteome Mapping Analysis Reveals Distinct Regional Differences in the Cardiac Proteome.

Heywood W, Searle J, Collis R, Doykov I, Ashworth M, Sebire N Life (Basel). 2024; 14(8).

PMID: 39202712 PMC: 11355120. DOI: 10.3390/life14080970.

Integrated Spatial Multi-Omics Study of Postmortem Brains of Alzheimer's Disease.

Toyama Y, Nirasawa T, Morishima M, Saito Y, Irie K, Murayama S Acta Histochem Cytochem. 2024; 57(3):119-130.

PMID: 38988692 PMC: 11231568. DOI: 10.1267/ahc.24-00025.

Highly Sensitive Spatial Glycomics at Near-Cellular Resolution by On-Slide Derivatization and Mass Spectrometry Imaging.

Cumin C, Gee L, Litfin T, Muchabaiwa R, Martin G, Cooper O Anal Chem. 2024; 96(28):11163-11171.

PMID: 38953530 PMC: 11256013. DOI: 10.1021/acs.analchem.3c05984.

Recent Developments and Application of Mass Spectrometry Imaging in N-Glycosylation Studies: An Overview.

Kumar B Mass Spectrom (Tokyo). 2024; 13(1):A0142.

PMID: 38435075 PMC: 10904931. DOI: 10.5702/massspectrometry.A0142.

Perspectives on pediatric congenital aortic valve stenosis: Extracellular matrix proteins, post translational modifications, and proteomic strategies.

Clift C, Saunders J, Drake R, Angel P Front Cardiovasc Med. 2022; 9:1024049.

PMID: 36439995 PMC: 9685993. DOI: 10.3389/fcvm.2022.1024049.

References

Hardesty W, Kelley M, Mi D, Low R, Caprioli R . Protein signatures for survival and recurrence in metastatic melanoma. J Proteomics. 2011; 74(7):1002-14. PMC: 3178099. DOI: 10.1016/j.jprot.2011.04.013. View

Zavalin A, Todd E, Rawhouser P, Yang J, Norris J, Caprioli R . Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS. J Mass Spectrom. 2012; 47(11):1473-81. DOI: 10.1002/jms.3108. View

Norris J, Caprioli R . Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem Rev. 2013; 113(4):2309-42. PMC: 3624074. DOI: 10.1021/cr3004295. View

Gustafsson O, Briggs M, Condina M, Winderbaum L, Pelzing M, McColl S . MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney. Anal Bioanal Chem. 2014; 407(8):2127-39. PMC: 4357650. DOI: 10.1007/s00216-014-8293-7. View

Robichaud G, Garrard K, Barry J, Muddiman D . MSiReader: an open-source interface to view and analyze high resolving power MS imaging files on Matlab platform. J Am Soc Mass Spectrom. 2013; 24(5):718-21. PMC: 3693088. DOI: 10.1007/s13361-013-0607-z. View

Yang J, Caprioli R . Matrix sublimation/recrystallization for imaging proteins by mass spectrometry at high spatial resolution. Anal Chem. 2011; 83(14):5728-34. PMC: 3136623. DOI: 10.1021/ac200998a. View

Holst S, Heijs B, de Haan N, van Zeijl R, Briaire-de Bruijn I, van Pelt G . Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues. Anal Chem. 2016; 88(11):5904-13. DOI: 10.1021/acs.analchem.6b00819. View

Seeley E, Oppenheimer S, Mi D, Chaurand P, Caprioli R . Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections. J Am Soc Mass Spectrom. 2008; 19(8):1069-77. PMC: 2582528. DOI: 10.1016/j.jasms.2008.03.016. View

Manasek F, Reid M, Vinson W, SEYER J, Johnson R . Glycosaminoglycan synthesis by the early embryonic chick heart. Dev Biol. 1973; 35(2):332-48. DOI: 10.1016/0012-1606(73)90028-6. View

10.

Hankin J, Barkley R, Murphy R . Sublimation as a method of matrix application for mass spectrometric imaging. J Am Soc Mass Spectrom. 2007; 18(9):1646-52. PMC: 2042488. DOI: 10.1016/j.jasms.2007.06.010. View

11.

Jefferis R . Posttranslational Modifications and the Immunogenicity of Biotherapeutics. J Immunol Res. 2016; 2016:5358272. PMC: 4848426. DOI: 10.1155/2016/5358272. View

12.

Zavalin A, Yang J, Hayden K, Vestal M, Caprioli R . Tissue protein imaging at 1 μm laser spot diameter for high spatial resolution and high imaging speed using transmission geometry MALDI TOF MS. Anal Bioanal Chem. 2015; 407(8):2337-42. PMC: 4359058. DOI: 10.1007/s00216-015-8532-6. View

13.

Angel P, Lim J, Wells L, Bergmann C, Orlando R . A potential pitfall in 18O-based N-linked glycosylation site mapping. Rapid Commun Mass Spectrom. 2007; 21(5):674-82. DOI: 10.1002/rcm.2874. View

14.

Lagarrigue M, Becker M, Lavigne R, Deininger S, Walch A, Aubry F . Revisiting rat spermatogenesis with MALDI imaging at 20-microm resolution. Mol Cell Proteomics. 2010; 10(3):M110.005991. PMC: 3047165. DOI: 10.1074/mcp.M110.005991. View

15.

Schey K, Anderson D, L Rose K . Spatially-directed protein identification from tissue sections by top-down LC-MS/MS with electron transfer dissociation. Anal Chem. 2013; 85(14):6767-74. PMC: 3749783. DOI: 10.1021/ac400832w. View

16.

Schey K, Gutierrez D, Wang Z, Wei J, Grey A . Novel fatty acid acylation of lens integral membrane protein aquaporin-0. Biochemistry. 2010; 49(45):9858-65. PMC: 3831505. DOI: 10.1021/bi101415w. View

17.

Catherman A, Skinner O, Kelleher N . Top Down proteomics: facts and perspectives. Biochem Biophys Res Commun. 2014; 445(4):683-93. PMC: 4103433. DOI: 10.1016/j.bbrc.2014.02.041. View

18.

Shoulders M, Raines R . Collagen structure and stability. Annu Rev Biochem. 2009; 78:929-58. PMC: 2846778. DOI: 10.1146/annurev.biochem.77.032207.120833. View

19.

De Sio G, Smith A, Galli M, Garancini M, Chinello C, Bono F . A MALDI-Mass Spectrometry Imaging method applicable to different formalin-fixed paraffin-embedded human tissues. Mol Biosyst. 2015; 11(6):1507-14. DOI: 10.1039/c4mb00716f. View

20.

Siuti N, Kelleher N . Decoding protein modifications using top-down mass spectrometry. Nat Methods. 2007; 4(10):817-21. PMC: 2365886. DOI: 10.1038/nmeth1097. View