Large Mitochondrial Genome and Mitochondrial DNA Size Polymorphism in the Mosquito Parasite, Romanomermis Culicivorax

Overview

Journal Curr Genet

Specialty Genetics

Date 1986 Jan 1

PMID 2834082

Citations 17

Authors

T O Powers

E G Platzer

B C Hyman

Affiliations

Soon will be listed here.

Abstract

Physical characterization of the mitochondrial genome derived from the obligate mosquito parasite, Romanomermis culicivorax has generated some surprising physical properties regarding the molecular structure of nematode mitochondrial DNA (mtDNA). Restriction enzyme analysis of this mtDNA has revealed a mitochondrial genome size of approximately 26 kb, the largest metazoan mtDNA reported to date. Isofemale lineages are monomorphic for one of three size variants, differing by 500-1,000 base pairs, present in our original field population. Cloned hybridization probes derived from a single region exhibiting a 600 bp size polymorphism share strong homology with several spatially separated sites distributed about the mtDNA. This suggests that the homology is a result of repeated DNA sequence elements contained within this mitochondrial genome that contribute to mtDNA size polymorphism.

Citing Articles

Metagenomic Analysis of Bacteria, Fungi, Bacteriophages, and Helminths in the Gut of Giant Pandas.

Yang S, Gao X, Meng J, Zhang A, Zhou Y, Long M Front Microbiol. 2018; 9:1717.

PMID: 30108570 PMC: 6080571. DOI: 10.3389/fmicb.2018.01717.

Rampant gene rearrangement and haplotype hypervariation among nematode mitochondrial genomes.

Hyman B, Lewis S, Tang S, Wu Z Genetica. 2010; 139(5):611-5.

PMID: 21136141 PMC: 3089818. DOI: 10.1007/s10709-010-9531-3.

Allomermis solenopsi n. sp. (Nematoda: Mermithidae) parasitising the fire ant Solenopsis invicta Buren (Hymenoptera: Formicidae) in Argentina.

Poinar Jr G, Porter S, Tang S, Hyman B Syst Parasitol. 2007; 68(2):115-28.

PMID: 17912617 DOI: 10.1007/s11230-007-9102-x.

Mitochondrial genome haplotype hypervariation within the isopod parasitic nematode Thaumamermis cosgrovei.

Tang S, Hyman B Genetics. 2007; 176(2):1139-50.

PMID: 17435228 PMC: 1894580. DOI: 10.1534/genetics.106.069518.

Atypical mitochondrial DNA from the deep-sea scallop Placopecten magellanicus.

Snyder M, Fraser A, Laroche J, Gartner-Kepkay K, Zouros E Proc Natl Acad Sci U S A. 1987; 84(21):7595-9.

PMID: 16593887 PMC: 299346. DOI: 10.1073/pnas.84.21.7595.

References

Avise J, Bermingham E, Kessler L, Saunders N . CHARACTERIZATION OF MITOCHONDRIAL DNA VARIABILITY IN A HYBRID SWARM BETWEEN SUBSPECIES OF BLUEGILL SUNFISH (LEPOMIS MACROCHIRUS). Evolution. 2017; 38(5):931-941. DOI: 10.1111/j.1558-5646.1984.tb00364.x. View

Borst P, Overdulve J, Weijers P, van den Berg M . DNA circles with cruciforms from Isospora (Toxoplasma) gondii. Biochim Biophys Acta. 1984; 781(1-2):100-11. DOI: 10.1016/0167-4781(84)90128-3. View

Hyman B, Bainbridge B, James T . Resolution of mitochondrial DNA structures in the large yeast Wickerhamia fluorescens. Exp Cell Res. 1982; 141(1):221-30. DOI: 10.1016/0014-4827(82)90084-2. View

Powers T, Platzer E, Hyman B . Species-Specific Restriction Site Polymorphism in Root-knot Nematode Mitochondrial DNA. J Nematol. 2009; 18(3):288-93. PMC: 2618552. View

HARRISON R, Rand D, Wheeler W . Mitochondrial DNA size variation within individual crickets. Science. 1985; 228(4706):1446-8. DOI: 10.1126/science.228.4706.1446. View

Sederoff R . Structural variation in mitochondrial DNA. Adv Genet. 1984; 22:1-108. DOI: 10.1016/s0065-2660(08)60038-3. View

Lansman R, Avise J, Aquadro C, Shapira J, Daniel S . EXTENSIVE GENETIC VARIATION IN MITOCHONDRIAL DNA'S AMONG GEOGRAPHIC POPULATIONS OF THE DEER MOUSE, PEROMYSCUS MANICULATUS. Evolution. 2017; 37(1):1-16. DOI: 10.1111/j.1558-5646.1983.tb05509.x. View

Hyman B, Cramer J, Rownd R . Properties of a Saccharomyces cerevisiae mtDNA segment conferring high-frequency yeast transformation. Proc Natl Acad Sci U S A. 1982; 79(5):1578-82. PMC: 346018. DOI: 10.1073/pnas.79.5.1578. View

Solignac M, Monnerot M, Mounolou J . Mitochondrial DNA heteroplasmy in Drosophila mauritiana. Proc Natl Acad Sci U S A. 1983; 80(22):6942-6. PMC: 390102. DOI: 10.1073/pnas.80.22.6942. View

10.

Bogler S, Zarley C, Burianek L, Fuerst P, Byers T . Interstrain mitochondrial DNA polymorphism detected in Acanthamoeba by restriction endonuclease analysis. Mol Biochem Parasitol. 1983; 8(2):145-63. DOI: 10.1016/0166-6851(83)90006-3. View

11.

Densmore L, Wright J, Brown W . Length variation and heteroplasmy are frequent in mitochondrial DNA from parthenogenetic and bisexual lizards (genus Cnemidophorus). Genetics. 1985; 110(4):689-707. PMC: 1202587. DOI: 10.1093/genetics/110.4.689. View

12.

WOLSTENHOLME D, Clary D . Sequence evolution of Drosophila mitochondrial DNA. Genetics. 1985; 109(4):725-44. PMC: 1202504. DOI: 10.1093/genetics/109.4.725. View

13.

Fauron C, WOLSTENHOLME D . Intraspecific diversity of nucleotide sequences within the adenine + thymine-rich region of mitochondrial DNA molecules of Drosophila mauritiana, Drosophila melanogaster and Drosophila simulans. Nucleic Acids Res. 1980; 8(22):5391-410. PMC: 324309. DOI: 10.1093/nar/8.22.5391. View

14.

Fauron C, WOLSTENHOLME D . Structural heterogeneity of mitochondrial DNA molecules within the genus Drosophila. Proc Natl Acad Sci U S A. 1976; 73(10):3623-7. PMC: 431170. DOI: 10.1073/pnas.73.10.3623. View

15.

Handel M, Papaconstantinou J, Allison D, Julku E, Chin E . Synthesis of mitochondrial DNA in spermatocytes of Rhynchosciara hollaenderi. Dev Biol. 1973; 35(2):240-9. DOI: 10.1016/0012-1606(73)90021-3. View

16.

Williamson D, Wilson R, Bates P, Mccready S, Perler F, Qiang B . Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi. Mol Biochem Parasitol. 1985; 14(2):199-209. DOI: 10.1016/0166-6851(85)90038-6. View

17.

Fauron C, WOLSTENHOLME D . Extensive diversity among Drosophila species with respect to nucleotide sequences within the adenine + thymine-rich region of mitochondrial DNA molecules. Nucleic Acids Res. 1980; 8(11):2439-52. PMC: 324092. DOI: 10.1093/nar/8.11.2439. View

18.

Clary D, Goddard J, Martin S, Fauron C, WOLSTENHOLME D . Drosophila mitochondrial DNA: a novel gene order. Nucleic Acids Res. 1982; 10(21):6619-37. PMC: 326953. DOI: 10.1093/nar/10.21.6619. View