Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems As Potential Anti-Inflammatory Agents

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 Mar 25

PMID 28338602

Citations 11

Authors

Eman S Nossier

Hoda H Fahmy

Nagy M Khalifa

Wafaa I El-Eraky

Marawan A Baset

Affiliations

Soon will be listed here.

Abstract

With the aim of developing novel anti-inflammatory scaffolds, a new series of pyrazole-substituted various nitrogenous heterocyclic ring systems at C-4 position were synthesized through different chemical reactions and validated by means of spectral and elemental data. The new obtained compounds were investigated for their anti-inflammatory activity using the carrageenan-induced paw edema standard technique and revealed that, compound showed increased potency with % inhibition of edema 85.23 ± 1.92 and 85.78 ± 0.99, respectively, higher than the standard reference drugs indomethacin and celebrex (72.99% and 83.76%). Molecular modeling studies were initiated herein to validate the attained pharmacological data and provide understandable evidence for the observed anti-inflammatory behavior.

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