Sex-dependent Effects of Neonatal Maternal Deprivation on Endocannabinoid Levels in the Adipose Tissue: Influence of Diet

Overview

Journal J Physiol Biochem

Specialties Biochemistry
Physiology

Date 2017 Mar 25

PMID 28337718

Citations 1

Authors

Virginia Mela

Fabiana Piscitelli

Alvaro Llorente Berzal

Julie Chowen

Cristoforo Silvestri

Maria Paz Viveros

Vincenzo Di Marzo

Affiliations

Soon will be listed here.

Abstract

Maternal deprivation (MD) during neonatal life has diverse long-term effects, including modification of metabolism. We have previously reported that MD modifies the metabolic response to high-fat diet (HFD) intake, with this response being different between males and females, while previous studies indicate that in mice with HFD-induced obesity, endocannabinoid (EC) levels are markedly altered in various brown and white adipose tissue depots. Here, we analyzed the effects of MD (24 h at postnatal day 9), alone or in combination with a HFD from weaning until the end of the experiment in Wistar rats of both sexes. Brown and white perirenal and subcutaneous adipose tissues were collected and the levels of anandamide (AEA), 2-arachidonoylglycerol (2-AG), palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) were determined. In males, MD increased the content of OEA in brown and 2-AG in subcutaneous adipose tissues, while in females the content of 2-AG was increased in perirenal fat. Moreover, in females, MD decreased AEA and OEA levels in perirenal and subcutaneous adipose tissues, respectively. HFD decreased the content of 2-AG in brown fat of both sexes and OEA in brown and subcutaneous adipose tissue of control females. In contrast, in subcutaneous fat, HFD increased AEA levels in MD males and OEA levels in control and MD males. The present results show for the first time that MD and HFD induce sex-dependent effects on the main ECs, AEA, and 2-AG, and of AEA-related mediators, OEA and PEA, in the rat brown and white (visceral and subcutaneous) adipose tissues.

Citing Articles

Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment.

Pepper I, Vinik A, Lattanzio F, McPheat W, Dobrian A Front Endocrinol (Lausanne). 2019; 10:311.

PMID: 31156558 PMC: 6533883. DOI: 10.3389/fendo.2019.00311.

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