Receptor for Advanced Glycation End As Drug Targets in Diabetes-induced Skin Lesion

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2017 Mar 25

PMID 28337263

Citations 3

Authors

Xiang-Fang Chen

Wei Tang

Wei-Dong Lin

Zi-Yu Liu

Xiao-Xiao Lu

Bei Zhang

Fei Ye

Zhi-Min Liu

Jun-Jie Zou

Wan-Qing Liao

Affiliations

Soon will be listed here.

Abstract

The involvement of the receptor for advanced glycation end (RAGE) in different diseases has been reviewed in great detail, previously, but the effects of diabetic drugs on RAGE-induced skin lesion during long course diabetes remains poorly understood. In the present study, we have shown that RAGE was overexpressed in both diabetic rats and human keratinocytes (HaCaT cells). Cell cycle arrest and apoptosis as well as alternations of relative protein levels were also found in diabetic rats and HaCaT cells with overexpression of RAGE that were rectified by metformin (Met) treatment. Moreover, overexpression of RAGE was also found to induce secretions of TNF-α, IL-1β, IL-6, ICAM-1 and COX-2 in HaCaT cells, and Met treatment corrected these inflammatory factor secretions. In addition, treatment with Met markedly reduced RAGE overexpression-induced p38 and NF-κB activation. Taken together, the findings of the present study have demonstrated, for the first time that Met protects HaCaT cells against diabetes-induced injuries and inflammatory responses through inhibiting activated RAGE.

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