Tmeff2 is Expressed in Differentiating Oligodendrocytes but Dispensable for Their Differentiation in Vivo

Overview

Journal Sci Rep

Specialty Science

Date 2017 Mar 25

PMID 28336932

Citations 6

Authors

Hao Huang

Peng Teng

Ruyi Mei

Aifen Yang

Zunyi Zhang

Xiaofeng Zhao

Mengsheng Qiu

Affiliations

Soon will be listed here.

Abstract

Myelin elaborated by oligodendrocytes (OLs) in the central nervous system (CNS) is required for saltatory conduction of action potentials along neuronal axons. We found that TMEFF2, a transmembrane protein with EGF-like and two follistatin-like domains, is selectively expressed in differentiating/myelinating OLs. Previous studies showed that TMEFF2 is capable of binding to PDGFA, which plays important roles in the proliferation, migration and differentiation of oligodendrocyte progenitor cells (OPCs). However, molecular and genetic analysis revealed that Tmeff2 is a weak binder of PDGFA, and not required for OL differentiation and myelin gene expression in vivo. Together, our data suggested that Tmeff2 is specifically upregulated in OLs, but dispensable for OL differentiation and maturation.

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