Pregnancy Vaccination with Gold Glyco-Nanoparticles Carrying Listeria Monocytogenes Peptides Protects Against Listeriosis and Brain- and Cutaneous-Associated Morbidities

Overview

Journal Nanomaterials (Basel)

Date 2017 Mar 25

PMID 28335280

Citations 20

Authors

Ricardo Calderon-Gonzalez

Hector Teran-Navarro

Elisabet Frande-Cabanes

Eva Ferrandez-Fernandez

Javier Freire

Soledad Penades

Marco Marradi

Isabel Garcia

Javier Gomez-Roman

Sonsoles Yanez-Diaz

Carmen Alvarez-Dominguez

Affiliations

Soon will be listed here.

Abstract

Listeriosis is a fatal infection for fetuses and newborns with two clinical main morbidities in the neonatal period, meningitis and diffused cutaneous lesions. In this study, we vaccinated pregnant females with two gold glyconanoparticles (GNP) loaded with two peptides, listeriolysin peptide 91-99 (LLO) or glyceraldehyde-3-phosphate dehydrogenase 1-22 peptide (GAPDH). Neonates born to vaccinated mothers were free of bacteria and healthy, while non-vaccinated mice presented clear brain affections and cutaneous diminishment of melanocytes. Therefore, these nanoparticle vaccines are effective measures to offer pregnant mothers at high risk of listeriosis interesting therapies that cross the placenta.

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