Clonal Rearrangement for Immunoglobulin and T-cell Receptor Genes in Systemic Castleman's Disease. Association with Epstein-Barr Virus

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1988 Apr 1

PMID 2833104

Citations 7

Authors

C A Hanson

G Frizzera

D F Patton

B A Peterson

K L McClain

J H Kersey

Affiliations

Soon will be listed here.

Abstract

Castleman's disease is a morphologically and clinically heterogeneous lymphoproliferative disorder. Both a localized benign variant and an aggressive form with systemic manifestations have been described. To investigate the differences between these variants of Castleman's disease, the authors analyzed lymph node DNA from 4 patients with the localized type and 4 with the systemic type of Castleman's disease for immunoglobulin and T-cell receptor gene rearrangements. The role of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) was also studied by viral genomic DNA probes. They detected clonal rearrangements in 3 of the 4 patients with the systemic variant of Castleman's; no patients with localized disease had rearrangements. Copies of EBV genome were also detected in 2 of the 3 patients with clonal rearrangements. These results suggest that systemic Castleman's disease is a disorder distinct from the classical localized variant in that it may evolve into a clonal lymphoproliferation.

Citing Articles

A Review of Genetic Abnormalities in Unicentric and Multicentric Castleman Disease.

Butzmann A, Kumar J, Sridhar K, Gollapudi S, Ohgami R Biology (Basel). 2021; 10(4).

PMID: 33804823 PMC: 8063830. DOI: 10.3390/biology10040251.

Clinical Analysis of Castleman's Disease of the Lacrimal Gland.

Li D, Tang D, Sun F J Ophthalmol. 2021; 2020:3718305.

PMID: 33489328 PMC: 7803145. DOI: 10.1155/2020/3718305.

Lymphotropic herpes virus (EBV, HHV-6, HHV-8) DNA sequences in HIV negative Castleman's disease.

Barozzi P, Luppi M, Masini L, Marasca R, Savarino M, Morselli M Clin Mol Pathol. 1996; 49(4):M232-5.

PMID: 16696081 PMC: 408065. DOI: 10.1136/mp.49.4.m232.

Cellular localisation of HHV-8 in Castleman's disease: is there a link with lymph node vascularity?.

OLeary J, Kennedy M, Howells D, Silva I, Uhlmann V, Luttich K Mol Pathol. 2000; 53(2):69-76.

PMID: 10889905 PMC: 1186908. DOI: 10.1136/mp.53.2.69.

Genetic changes in atypical hyperplasia and lymphoma with angioimmunoblastic lymphadenopathy and dysproteinaemia in the same patients.

Ohshima K, Kikuchi M, Hashimoto M, Kozuru M, Uike N, Kobari S Virchows Arch. 1994; 425(1):25-32.

PMID: 7921409 DOI: 10.1007/BF00193945.

References

Ho M, Miller G, ATCHISON R, BREINIG M, Dummer J, Andiman W . Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: the role of primary infection. J Infect Dis. 1985; 152(5):876-86. PMC: 3154749. DOI: 10.1093/infdis/152.5.876. View

Artusi T, Bonacorsi G, Saragoni A, Spedicato M, Rinaldi G, Federico M . Castleman's lymphoadenopathy: twenty years of observation. II. Generalized form. Haematologica. 1982; 67(1):124-42. View

Birx D, Redfield R, Tosato G . Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders. N Engl J Med. 1986; 314(14):874-9. DOI: 10.1056/NEJM198604033141403. View

Hsu S, RAINE L, FANGER H . Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981; 29(4):577-80. DOI: 10.1177/29.4.6166661. View

Frizzera G, Peterson B, BAYRD E, Goldman A . A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol. 1985; 3(9):1202-16. DOI: 10.1200/JCO.1985.3.9.1202. View

Arnold A, Cossman J, Bakhshi A, Jaffe E, Waldmann T, Korsmeyer S . Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med. 1983; 309(26):1593-9. DOI: 10.1056/NEJM198312293092601. View

Hanto D, Frizzera G, Simmons R . Epstein-Barr virus, immunodeficiency, and B cell lymphoproliferation. Transplantation. 1985; 39(5):461-72. DOI: 10.1097/00007890-198505000-00001. View

Couch W . Giant lymph node hyperplasia associated with thrombotic thrombocytopenic purpura. Am J Clin Pathol. 1980; 74(3):340-4. DOI: 10.1093/ajcp/74.3.340. View

Kessler E, Beer R . Multicentric giant lymph node hyperplasia clinically simulating angioimmunoblastic lymphadenopathy. Associated Kaposi's sarcoma in two of three cases. Isr J Med Sci. 1983; 19(3):230-4. View

10.

Weiss L, Wood G, Trela M, Warnke R, Sklar J . Clonal T-cell populations in lymphomatoid papulosis. Evidence of a lymphoproliferative origin for a clinically benign disease. N Engl J Med. 1986; 315(8):475-9. DOI: 10.1056/NEJM198608213150802. View

11.

Andiman W, Gradoville L, Heston L, Neydorff R, Savage M, Kitchingman G . Use of cloned probes to detect Epstein-Barr viral DNA in tissues of patients with neoplastic and lymphoproliferative diseases. J Infect Dis. 1983; 148(6):967-77. DOI: 10.1093/infdis/148.6.967. View

12.

Penn I . Kaposi's sarcoma in organ transplant recipients: report of 20 cases. Transplantation. 1979; 27(1):8-11. DOI: 10.1097/00007890-197901000-00003. View

13.

Rambaldi A, Pelicci P, Allavena P, Knowles 2nd D, Rossini S, Bassan R . T cell receptor beta chain gene rearrangements in lymphoproliferative disorders of large granular lymphocytes/natural killer cells. J Exp Med. 1985; 162(6):2156-62. PMC: 2187976. DOI: 10.1084/jem.162.6.2156. View

14.

Korsmeyer S, Arnold A, Bakhshi A, Ravetch J, Siebenlist U, Hieter P . Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J Clin Invest. 1983; 71(2):301-13. PMC: 436868. DOI: 10.1172/jci110770. View

15.

Frizzera G . Castleman's disease: more questions than answers. Hum Pathol. 1985; 16(3):202-5. DOI: 10.1016/s0046-8177(85)80002-2. View

16.

Feinberg A, Vogelstein B . A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983; 132(1):6-13. DOI: 10.1016/0003-2697(83)90418-9. View

17.

Thomsen D, Stinski M . Cloning of the human cytomegalovirus genome as endonuclease XbaI fragments. Gene. 1981; 16(1-3):207-16. DOI: 10.1016/0378-1119(81)90077-9. View

18.

Weisenburger D, Nathwani B, Winberg C, Rappaport H . Multicentric angiofollicular lymph node hyperplasia: a clinicopathologic study of 16 cases. Hum Pathol. 1985; 16(2):162-72. DOI: 10.1016/s0046-8177(85)80065-4. View

19.

Tawa A, Hozumi N, Minden M, Mak T, Gelfand E . Rearrangement of the T-cell receptor beta-chain gene in non-T-cell, non-B-cell acute lymphoblastic leukemia of childhood. N Engl J Med. 1985; 313(17):1033-7. DOI: 10.1056/NEJM198510243131701. View

20.

KELLER A, Hochholzer L, Castleman B . Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer. 1972; 29(3):670-83. DOI: 10.1002/1097-0142(197203)29:3<670::aid-cncr2820290321>3.0.co;2-#. View