IsoSel: Protein Isoform Selector for Phylogenetic Reconstructions

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Mar 22

PMID 28323858

Citations 3

Authors

Heloise Philippon

Alexia Souvane

Celine Brochier-Armanet

Guy Perriere

Affiliations

Soon will be listed here.

Abstract

The reliability of molecular phylogenies is strongly dependent on the quality of the assembled datasets. In the case of eukaryotes, the selection of only one protein isoform per genomic locus is mandatory to avoid biases linked to redundancy. Here, we present IsoSel, a tool devoted to the selection of alternative isoforms in the context of phylogenetic reconstruction. It provides a better alternative to the widely used approach consisting in the selection of the longest isoforms and it performs better than Guidance, its only available counterpart. IsoSel is publicly available at http://doua.prabi.fr/software/isosel.

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