Absence of Antiviral Activity in Recombinant B Cell Stimulatory Factor 2 (BSF-2)

Overview

Journal Immunol Lett

Specialty Allergy & Immunology

Date 1988 Jan 1

PMID 2832321

Citations 16

Authors

T Hirano

T Matsuda

K Hosoi

A Okano

H Matsui

T Kishimoto

Affiliations

Soon will be listed here.

Abstract

Recombinant B cell stimulatory factor 2 (rBSF-2) did not display any detectable level of antiviral activity when using human diploid fibroblasts, DIP-2, FS-4, FS-7, amnion-derived WISH and FL cells with vesicular stomatitis virus (VSV) and Sindbis virus as challenging agents (less than 2.5 X 10(2) IU/mg). Furthermore anti-IFN-beta could not neutralize the immunoglobulin-inducing activity of BSF-2. Moreover anti-BSF-2 could not neutralize the antiviral activity of IFN-beta. The data indicate that BSF-2 is functionally and immunologically not related to IFNs.

Citing Articles

Key Interleukins in Inflammatory Bowel Disease-A Review of Recent Studies.

Aebisher D, Bartusik-Aebisher D, Przygorzewska A, Oles P, Woznicki P, Kawczyk-Krupka A Int J Mol Sci. 2025; 26(1.

PMID: 39795980 PMC: 11719876. DOI: 10.3390/ijms26010121.

Interleukin-6 and Interferon-α Signaling JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States.

Danziger O, Pupko T, Bacharach E, Ehrlich M Front Immunol. 2018; 9:94.

PMID: 29441069 PMC: 5797546. DOI: 10.3389/fimmu.2018.00094.

Oncostatin M induces RIG-I and MDA5 expression and enhances the double-stranded RNA response in fibroblasts.

Hergovits S, Mais C, Haan C, Costa-Pereira A, Hermanns H J Cell Mol Med. 2017; 21(11):3087-3099.

PMID: 28560754 PMC: 5661242. DOI: 10.1111/jcmm.13221.

A critical role of the transcription factor fli-1 in murine lupus development by regulation of interleukin-6 expression.

Sato S, Richard M, Brandon D, Jones Buie J, Oates J, Gilkeson G Arthritis Rheumatol. 2014; 66(12):3436-44.

PMID: 25155007 PMC: 4245454. DOI: 10.1002/art.38818.

Interleukin-6: discovery of a pleiotropic cytokine.

Kishimoto T Arthritis Res Ther. 2006; 8 Suppl 2:S2.

PMID: 16899106 PMC: 3226075. DOI: 10.1186/ar1916.