Inverse Relationship Between Colonic (Na+ + K+)-ATPase Activity and Degree of Mucosal Inflammation in Inflammatory Bowel Disease

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1988 Apr 1

PMID 2832138

Citations 19

Authors

H Allgayer

W Kruis

G Paumgartner

B WIEBECKE

L Brown

E Erdmann

Affiliations

Soon will be listed here.

Abstract

In inflammatory bowel disease (IBD), mucosal damage and loss of colonic function are regarded as major consequences of inflammation. Decreased colonic (Na+ + K+)-ATPase activities with diminished reabsorption of sodium and water have been found in active stages of ulcerative colitis. In this study, we report an inverse relationship between colonic (Na+ + K+)-ATPase activity and the degree of mucosal inflammation in 19 patients with IBD of mild to moderate disease activity. Various macroscopic and histologic types of mucosal lesions were differently associated with the (Na+ + K+)-ATPase activities. 5'-nucleotidase activity was not associated with the degree of mucosal inflammation or the kind of macroscopic or histologic lesions. Our findings support the view that, in contrast to 5H-nucleotidase, (Na+ + K+)-ATPase activity may better reflect the severity of mucosal damage and the degree of inflammation in IBD.

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References

Sharon P, Karmeli F, Rachmilewitz D . Effect of prostanoids on human intestinal Na-K-ATPase activity. Isr J Med Sci. 1984; 20(8):677-80. View

Vatn M, Elgjo K, Norheim A, Bergan A . Measurement of enzyme activity in colonic biopsies: a test for premalignancy in ulcerative colitis?. Scand J Gastroenterol. 1984; 19(7):889-92. View

Allgayer H, Brown L, Kruis W, Erdmann E, Paumgartner G . Inhibition of human colonic (Na+ + K+)-ATPase by arachidonic and linoleic acid. Naunyn Schmiedebergs Arch Pharmacol. 1986; 332(4):398-402. DOI: 10.1007/BF00500094. View

Sharon P, Ligumsky M, Rachmilewitz D, ZOR U . Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology. 1978; 75(4):638-40. View

Gooptu D, TRUELOVE S, Warner G . Absorption of electrolytes from the colon in cases of ulcerative colitis and in control subjects. Gut. 1969; 10(7):555-61. PMC: 1552951. DOI: 10.1136/gut.10.7.555. View

Sharon P, Stenson W . Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology. 1984; 86(3):453-60. View

Best W, Becktel J, SINGLETON J, KERN Jr F . Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976; 70(3):439-44. View

Rampton D, Sladen G . The effect of sulphasalazine withdrawal on rectal mucosal function and prostaglandin E2 release in inactive ulcerative colitis. Scand J Gastroenterol. 1981; 16(1):157-9. View

TRUELOVE S, Witts L . Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955; 2(4947):1041-8. PMC: 1981500. DOI: 10.1136/bmj.2.4947.1041. View

10.

Frielle T, Curthoys N . Specific labelling of the hydrophobic domain of rat renal gamma-glutamyltransferase. Ciba Found Symp. 1983; 95:73-91. DOI: 10.1002/9780470720769.ch6. View

11.

Schoner W, von Ilberg C, Kramer R, SEUBERT W . On the mechanism of Na+- and K+-stimulated hydrolysis of adenosine triphosphate. 1. Purification and properties of a Na+-and K+-activated ATPase from ox brain. Eur J Biochem. 1967; 1(3):334-43. DOI: 10.1007/978-3-662-25813-2_45. View

12.

SOLYOM A, TRAMS E . Enzyme markers in characterization of isolated plasma membranes. Enzyme. 1972; 13(5-6):329-72. DOI: 10.1159/000459682. View

13.

Byrd J, Fearney F, Kim Y . Rat intestinal nucleotide-sugar pyrophosphatase. Localization, partial purification, and substrate specificity. J Biol Chem. 1985; 260(12):7474-80. View

14.

Stein D, Gray G, GREGORY P, Anderson M, Goodwin D, McDougall I . Location and activity of ulcerative and Crohn's colitis by indium 111 leukocyte scan. A prospective comparison study. Gastroenterology. 1983; 84(2):388-93. View

15.

Maier K, Fischer C, Klotz U, HEINKEL K . [5-Aminosalicylic acid in ulcerative colitis and Crohn's disease (author's transl)]. Dtsch Med Wochenschr. 1982; 107(29-30):1131-4. DOI: 10.1055/s-2008-1070088. View

16.

OMorain C, Smethurst P, Levi A, Peters T . Organelle pathology in ulcerative and Crohn's colitis with special reference to the lysosomal alterations. Gut. 1984; 25(5):455-9. PMC: 1432458. DOI: 10.1136/gut.25.5.455. View

17.

STIRLING C . Radioautographic localization of sodium pump sites in rabbit intestine. J Cell Biol. 1972; 53(3):704-14. PMC: 2108766. DOI: 10.1083/jcb.53.3.704. View

18.

LOWRY O, ROSEBROUGH N, FARR A, RANDALL R . Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75. View

19.

Hermanowicz A, Nawarska Z . Chemotaxis and random migration of polymorphonuclear leukocytes in ulcerative colitis examined by the agarose method. Scand J Gastroenterol. 1981; 16(8):961-6. DOI: 10.3109/00365528109181011. View

20.

Rachmilewitz D, Karmeli F, SELINGER Z . Increased colonic adenylate cyclase activity in active ulcerative colitis. Gastroenterology. 1983; 85(1):12-6. View