Early Peritoneal Dialysis Reduces Lung Inflammation in Mice with Ischemic Acute Kidney Injury

Overview

Journal Kidney Int

Publisher Elsevier

Specialty Nephrology

Date 2017 Mar 21

PMID 28318621

Citations 9

Authors

Chris Altmann

Nilesh Ahuja

Carol M Kiekhaefer

Ana Andres Hernando

Kayo Okamura

Rhea Bhargava

Jane Duplantis

Lara A Kirkbride-Romeo

Jill Huckles

Benjamin M Fox

Kashfi Kahn

Danielle Soranno

Hyo-Wook Gil

Isaac Teitelbaum

Sarah Faubel

Affiliations

Soon will be listed here.

Abstract

Although dialysis has been used in the care of patients with acute kidney injury (AKI) for over 50 years, very little is known about the potential benefits of uremic control on systemic complications of AKI. Since the mortality of AKI requiring renal replacement therapy (RRT) is greater than half in the intensive care unit, a better understanding of the potential of RRT to improve outcomes is urgently needed. Therefore, we sought to develop a technically feasible and reproducible model of RRT in a mouse model of AKI. Models of low- and high-dose peritoneal dialysis (PD) were developed and their effect on AKI, systemic inflammation, and lung injury after ischemic AKI was examined. High-dose PD had no effect on AKI, but effectively cleared serum IL-6, and dramatically reduced lung inflammation, while low-dose PD had no effect on any of these three outcomes. Both models of RRT using PD in AKI in mice reliably lowered urea in a dose-dependent fashion. Thus, use of these models of PD in mice with AKI has great potential to unravel the mechanisms by which RRT may improve the systemic complications that have led to increased mortality in AKI. In light of recent data demonstrating reduced serum IL-6 and improved outcomes with prophylactic PD in children, we believe that our results are highly clinically relevant.

Citing Articles

Acute Kidney Injury and Acute Respiratory Distress Syndrome.

Park B, Faubel S Crit Care Clin. 2021; 37(4):835-849.

PMID: 34548136 PMC: 8157315. DOI: 10.1016/j.ccc.2021.05.007.

Acute Kidney Injury in Hospitalized Children with COVID19.

Chopra S, Saha A, Kumar V, Thakur A, Pemde H, Kapoor D J Trop Pediatr. 2021; 67(2).

PMID: 34080011 PMC: 8195178. DOI: 10.1093/tropej/fmab037.

Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion.

Ambruso S, Gil H, Fox B, Park B, Altmann C, Bagchi R Am J Physiol Lung Cell Mol Physiol. 2021; 321(1):L50-L64.

PMID: 33949208 PMC: 8321856. DOI: 10.1152/ajplung.00042.2020.

Peritoneal Dialysis Is an Option for Acute Kidney Injury Management in Patients with COVID-19.

Rodriguez-Chagolla J, Jimenez E, Herrera Arellano L, Villa Torres A, Acosta Garcia N, Aleman Quimbiulco D Blood Purif. 2020; 50(3):283-289.

PMID: 33017826 PMC: 7573901. DOI: 10.1159/000511390.

Prophylactic Peritoneal Drainage is Associated with Improved Fluid Output after Congenital Heart Surgery.

Pettit K, Schreiter N, Lushaj E, Hermsen J, Wilhelm M, Mahon A Pediatr Cardiol. 2020; 41(8):1704-1713.

PMID: 32734528 PMC: 7391225. DOI: 10.1007/s00246-020-02431-x.

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