High Mobility Group Proteins 1 and 2 Stimulate Binding of a Specific Transcription Factor to the Adenovirus Major Late Promoter

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1988 Feb 25

PMID 2831501

Citations 34

Authors

F Watt

P L Molloy

Affiliations

Soon will be listed here.

Abstract

High mobility group proteins 1 and 2 (HMGs 1 and 2) are abundant chromosomal proteins which are believed to be preferentially associated with regions of active chromatin. Our previous results have shown that HMGs 1 and 2 can significantly stimulate specific transcription in vitro from the adenovirus major late promoter. This stimulation is now shown to be due, at least in part, to the influence of HMGs 1 and 2 on binding of a specific transcription factor (MLTF) upstream of the start site of the gene to a region (-66 to -51) which is required for optimal transcription both in vivo and in vitro. HMGs 1 and 2 cause both an increase in the rate of binding of the transcription factor to the DNA and alterations to the pattern of the DNaseI footprint of the factor on the DNA. Different binding states of the factor are also observed dependent on the presence of MgCl2, the factor being bound but not protecting the binding region from DNaseI in the absence of MgCl2.

Citing Articles

The protein composition of human adenovirus replication compartments.

Hidalgo P, Torres A, Jean Beltran P, Lopez-Leal G, Bertzbach L, Dobner T mBio. 2024; 16(1):e0214424.

PMID: 39611842 PMC: 11708036. DOI: 10.1128/mbio.02144-24.

Isolation and characterization of high-mobility-group proteins from maize.

Grasser K, Wurz A, Feix G Planta. 2013; 185(3):350-5.

PMID: 24186417 DOI: 10.1007/BF00201055.

The acidic C-terminal domain and A-box of HMGB-1 regulates p53-mediated transcription.

Banerjee S, Kundu T Nucleic Acids Res. 2003; 31(12):3236-47.

PMID: 12799451 PMC: 162246. DOI: 10.1093/nar/gkg412.

SSRP1 functions as a co-activator of the transcriptional activator p63.

Zeng S, Dai M, Keller D, Lu H EMBO J. 2002; 21(20):5487-97.

PMID: 12374749 PMC: 129072. DOI: 10.1093/emboj/cdf540.

Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein.

McKinney K, Prives C Mol Cell Biol. 2002; 22(19):6797-808.

PMID: 12215537 PMC: 134028. DOI: 10.1128/MCB.22.19.6797-6808.2002.

References

Hen R, Sassone-Corsi P, Corden J, Gaub M, Chambon P . Sequences upstream from the T-A-T-A box are required in vivo and in vitro for efficient transcription from the adenovirus serotype 2 major late promoter. Proc Natl Acad Sci U S A. 1982; 79(23):7132-6. PMC: 347292. DOI: 10.1073/pnas.79.23.7132. View

Reeck G, Isackson P, Teller D . Domain structure in high molecular weight high mobility group nonhistone chromatin proteins. Nature. 1982; 300(5887):76-8. DOI: 10.1038/300076a0. View

Carballo M, Puigdomenech P, Palau J . DNA and histone H1 interact with different domains of HMG 1 and 2 proteins. EMBO J. 1983; 2(10):1759-64. PMC: 555355. DOI: 10.1002/j.1460-2075.1983.tb01654.x. View

Chambers S, Rill R . Enrichment of transcribed and newly replicated DNA in soluble chromatin released from nuclei by mild micrococcal nuclease digestion. Biochim Biophys Acta. 1984; 782(2):202-9. DOI: 10.1016/0167-4781(84)90025-3. View

Jove R, Manley J . In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites. J Biol Chem. 1984; 259(13):8513-21. View

Carballo M, Puigdomenech P, Tancredi T, Palau J . Interaction between domains in chromosomal protein HMG-1. EMBO J. 1984; 3(6):1255-61. PMC: 557506. DOI: 10.1002/j.1460-2075.1984.tb01960.x. View

Cary P, Turner C, Leung I, Mayes E, Crane-Robinson C . Conformation and domain structure of the non-histone chromosomal proteins HMG 1 and 2. Domain interactions. Eur J Biochem. 1984; 143(2):323-30. DOI: 10.1111/j.1432-1033.1984.tb08375.x. View

Miyamoto N, Moncollin V, Wintzerith M, Hen R, Egly J, Chambon P . Stimulation of in vitro transcription by the upstream element of the adenovirus-2 major late promoter involves a specific factor. Nucleic Acids Res. 1984; 12(23):8779-99. PMC: 320419. DOI: 10.1093/nar/12.23.8779. View

Yu Y, Manley J . Generation and functional analyses for base-substitution mutants of the adenovirus 2 major late promoter. Nucleic Acids Res. 1984; 12(24):9309-21. PMC: 320463. DOI: 10.1093/nar/12.24.9309. View

10.

Ip M, MILHOLLAND R, Shea W, Dressler L . Binding of the glucocorticoid receptor complex to the nucleosomal core in the P1798 mouse lymphosarcoma. Mol Cell Endocrinol. 1985; 41(1):45-59. DOI: 10.1016/0303-7207(85)90141-8. View

11.

Sawadogo M, Roeder R . Factors involved in specific transcription by human RNA polymerase II: analysis by a rapid and quantitative in vitro assay. Proc Natl Acad Sci U S A. 1985; 82(13):4394-8. PMC: 390420. DOI: 10.1073/pnas.82.13.4394. View

12.

Sawadogo M, Roeder R . Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell. 1985; 43(1):165-75. DOI: 10.1016/0092-8674(85)90021-2. View

13.

Carthew R, Chodosh L, Sharp P . An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter. Cell. 1985; 43(2 Pt 1):439-48. DOI: 10.1016/0092-8674(85)90174-6. View

14.

Brown J, ANDERSON J . The binding of the chromosomal protein HMG-2a to DNA regions of reduced stabilities. J Biol Chem. 1986; 261(3):1349-54. View

15.

Miyamoto N, Moncollin V, Egly J, Chambon P . Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter. EMBO J. 1985; 4(13A):3563-70. PMC: 554698. DOI: 10.1002/j.1460-2075.1985.tb04118.x. View

16.

Bernues J, Espel E, Querol E . Identification of the core-histone-binding domains of HMG1 and HMG2. Biochim Biophys Acta. 1986; 866(4):242-51. DOI: 10.1016/0167-4781(86)90049-7. View

17.

Tremethick D, Molloy P . High mobility group proteins 1 and 2 stimulate transcription in vitro by RNA polymerases II and III. J Biol Chem. 1986; 261(15):6986-92. View

18.

Shi X, Lee R, Weinmann R . Protein factor(s) binding independently to two different regions of the adenovirus 2 major late promoter. Nucleic Acids Res. 1986; 14(9):3729-44. PMC: 339811. DOI: 10.1093/nar/14.9.3729. View

19.

Briggs M, Kadonaga J, Bell S, Tjian R . Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science. 1986; 234(4772):47-52. DOI: 10.1126/science.3529394. View

20.

Moncollin V, Miyamoto N, Zheng X, Egly J . Purification of a factor specific for the upstream element of the adenovirus-2 major late promoter. EMBO J. 1986; 5(10):2577-84. PMC: 1167155. DOI: 10.1002/j.1460-2075.1986.tb04537.x. View