Development of Anticancer Agents Targeting the Hedgehog Signaling

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2017 Mar 19

PMID 28314894

Citations 7

Authors

Xiangqian Zhang

Ye Tian

Yanling Yang

Jijun Hao

Affiliations

Soon will be listed here.

Abstract

Hedgehog signaling is an evolutionarily conserved pathway which is essential in embryonic and postnatal development as well as adult organ homeostasis. Abnormal regulation of Hedgehog signaling is implicated in many diseases including cancer. Consequently, substantial efforts have made in the past to develop potential therapeutic agents that specifically target the Hedgehog signaling for cancer treatment. Here, we review the therapeutic agents for inhibition of the Hedgehog signaling and their clinical advances in cancer treatment.

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