Nighttime Eating and Breast Cancer Among Chinese Women in Hong Kong

Overview

Journal Breast Cancer Res

Specialty Oncology

Date 2017 Mar 18

PMID 28302140

Citations 12

Authors

Mengjie Li

Lap Ah Tse

Wing-Cheong Chan

Chi-Hei Kwok

Siu-Lan Leung

Cherry Wu

Wai-Cho Yu

Priscilla Ming-Yi Lee

Koon-Ho Tsang

Sze-Hong Law

Roel Vermeulen

Fangyi Gu

Neil E Caporaso

Ignatius Tak-Sun Yu

Feng Wang

Xiaohong Rose Yang

Affiliations

Soon will be listed here.

Abstract

Background: A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits after 10 p.m. and breast cancer in Hong Kong women.

Methods: A hospital-based case-control study was conducted during 2012-2015. A total of 922 patients with incident breast cancer (cases) and 913 hospital controls were recruited and interviewed using a standard questionnaire including information on eating behavior during both daytime and nighttime. We collected the timing, duration, types and frequencies of food intake of eating at nighttime. Odds ratios (ORs) for the risk of breast cancer in relation to nighttime eating-related variables were calculated by unconditional multivariable logistic regression.

Results: Eating at night after 10 pm was significantly associated with breast cancer with an adjusted OR of 1.50 (95% confidence interval (CI) 1.06-2.12, P = 0.02), and the associations were stronger in women who had the longest duration of nighttime eating (≥20 years) (adjusted OR = 2.28 (95% CI 1.13-4.61, P = 0.02) and who ate late (midnight to 2 a.m.) (adjusted OR = 2.73, 95% CI 1.01-6.99, P = 0.04). Interestingly, nighttime eating was only associated with breast cancer among women who consumed staple foods (OR = 2.16, 95% CI 1.42-3.29, P < 0.001) but not those who ate vegetables or fruits as nighttime meals. The significant association between nighttime eating and breast cancer was observed among women with body mass index (BMI) <25 (OR = 2.29, 95% CI 1.48-3.52, P < 0.001) but not among women with BMI ≥25.

Conclusions: Results from this study suggest a possible association between nighttime eating behavior and breast cancer. These findings need to be confirmed by independent large studies.

Citing Articles

Comparison of the Effects of Inappropriate Meal Timing-Induced and Genetic Models of Circadian Clock Disruption on Uterine mRNA Expression Profiles.

Chen Y, Hosono T, Ono M, Daikoku T, Toyoda N, Nomura S J Nutr. 2024; 154(12):3718-3725.

PMID: 39395574 PMC: 11662237. DOI: 10.1016/j.tjnut.2024.10.011.

Night eating in timing, frequency, and food quality and risks of all-cause, cancer, and diabetes mortality: findings from national health and nutrition examination survey.

Wang P, Tan Q, Zhao Y, Zhao J, Zhang Y, Shi D Nutr Diabetes. 2024; 14(1):5.

PMID: 38413565 PMC: 10899630. DOI: 10.1038/s41387-024-00266-6.

Molecular crosstalk between circadian clock and cancer and therapeutic implications.

Qu M Front Nutr. 2023; 10:1143001.

PMID: 36937362 PMC: 10017454. DOI: 10.3389/fnut.2023.1143001.

Obesity, cancer risk, and time-restricted eating.

Das M, Webster N Cancer Metastasis Rev. 2022; 41(3):697-717.

PMID: 35984550 PMC: 9470651. DOI: 10.1007/s10555-022-10061-3.

Time-Restricted Feeding Studies and Possible Human Benefit.

Boyd P, OConnor S, Heckman-Stoddard B, Sauter E JNCI Cancer Spectr. 2022; 6(3).

PMID: 35657339 PMC: 9165551. DOI: 10.1093/jncics/pkac032.

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