Genetic Alterations in TRAF3 and CYLD That Regulate Nuclear Factor κB and Interferon Signaling Define Head and Neck Cancer Subsets Harboring Human Papillomavirus

Overview

Journal Cancer

Publisher Wiley

Specialty Oncology

Date 2017 Mar 16

PMID 28295216

Citations 4

Authors

Tony Chen

Jialing Zhang

Zhong Chen

Carter Van Waes

Affiliations

Soon will be listed here.

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NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer.

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Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.

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References

Mathis B, Lai Y, Qu C, Janicki J, Cui T . CYLD-mediated signaling and diseases. Curr Drug Targets. 2014; 16(4):284-94. PMC: 4418510. DOI: 10.2174/1389450115666141024152421. View

Font-Burgada J, Seki E, Karin M . CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012; 21(6):711-2. PMC: 4718070. DOI: 10.1016/j.ccr.2012.05.034. View

Van Waes C . Nuclear factor-kappaB in development, prevention, and therapy of cancer. Clin Cancer Res. 2007; 13(4):1076-82. DOI: 10.1158/1078-0432.CCR-06-2221. View

. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015; 517(7536):576-82. PMC: 4311405. DOI: 10.1038/nature14129. View

Hacker H, Tseng P, Karin M . Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol. 2011; 11(7):457-68. DOI: 10.1038/nri2998. View