STNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease

Overview

Journal Open Access Maced J Med Sci

Specialty General Medicine

Date 2017 Mar 16

PMID 28293320

Citations 2

Authors

Rajnish K Singhal

Balwant Rai

Affiliations

Soon will be listed here.

Abstract

Background: Different studies have implicated the exposure to systemic conditions in the aetiology of cardiovascular diseases like chronic inflammation including chronic periodontitis.

Aim: The present study has been conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic marker of inflammation and has been identified as risk factors for cardiovascular diseases.

Material And Methods: sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged 20-45 years and in 20 control patients without periodontitis (M:F::10:10, aged 20-48 years). Measurement of sTNF-R1 and sTNF-R2 was carried out in duplicate with standardised, commercially available enzyme immunoassays (R&D Systems Europe, Abingdon, UK).

Results: The mean sTNF-R1 and sTNF-R2 levels in periodontitis were 820 (240) pg/ml (413 - 1620 pg/ml) and 1309 (403) pg/ml (540 - 2430 pg/ml), while in normal sTNF-R1 and sTNF - R2 levels were 740 (340) pg/ml (407-1240 pg/ml) and 1283 (414) pg (480 - 2340 pg/ml) respectively. Results indicated a positive high relationship between cardiovascular markers such as sTNF-R1 and sTNF - R2 and apical periodontitis.

Conclusion: Elevated levels of sTNF-R1 and sTNF - R2 in apical periodontitis patients indicate an increased independent risk of coronary heart disease.

Citing Articles

Prevalence of Apical Periodontitis in patients with Multiple Myeloma.

Onate-Sanchez R, Perez-Diaz S, Rodriguez-Lozano F, Guerrero-Girones J Med Oral Patol Oral Cir Bucal. 2020; 25(3):e383-e387.

PMID: 32134898 PMC: 7211371. DOI: 10.4317/medoral.23416.

Retraction: Singhal R, Rai B. sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease. Open Access Maced J Med Sci. 2017; 5(1):68-1.

Spiroski M Open Access Maced J Med Sci. 2019; 7(10):1691.

PMID: 31231433 PMC: 6560296. DOI: 10.3889/oamjms.2019.225.

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