A Cascade of Multiple Proteins and Lipids Catalyzes Membrane Fusion

Overview

Journal Mol Biol Cell

Specialties Cell Biology
Molecular Biology

Date 2017 Mar 16

PMID 28292915

Citations 54

Authors

William Wickner

Josep Rizo

Affiliations

Soon will be listed here.

Abstract

Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into -complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.

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