Viral Infections and Obesity

Overview

Journal Curr Obes Rep

Specialty Endocrinology

Date 2017 Mar 15

PMID 28290153

Citations 15

Authors

Jameson D Voss

Nikhil V Dhurandhar

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Obesity is a multifactorial disease that is now endemic throughout most of the world. Although addressing proximate causes of obesity (excess energy intake and reduced energy expenditure) have been longstanding global health priorities, the problem has continued to worsen at the global level.

Recent Findings: Numerous microbial agents cause obesity in various experimental models-a phenomena known as infectobesity. Several of the same agents alter metabolic function in human cells and are associated with human obesity or metabolic dysfunction in humans. We address the evidence for a role in the genesis of obesity for viral agents in five broad categories: adenoviridae, herpesviridae, phages, transmissible spongiform encephalopathies (slow virus), and other encephalitides and hepatitides. Despite the importance of this topic area, there are many persistent knowledge gaps that need to be resolved. We discuss factors motivating further research and recommend that future infectobesity investigation should be more comprehensive, leveraged, interventional, and patient-centered.

Citing Articles

Identification of hub genes in the crosstalk between type 2 diabetic nephropathy and obesity according to bioinformatics analysis.

Shi S, Ding K, Chen F, Yang M, Ni L, Wu X Adipocyte. 2024; 13(1):2423723.

PMID: 39526504 PMC: 11556279. DOI: 10.1080/21623945.2024.2423723.

Sarcosine, Trigonelline and Phenylalanine as Urinary Metabolites Related to Visceral Fat in Overweight and Obesity.

Gurgel A, Batista A, de Paiva Cavalcanti D, Magalhaes A, Zantut-Wittmann D Metabolites. 2024; 14(9).

PMID: 39330498 PMC: 11434364. DOI: 10.3390/metabo14090491.

Immunogenetic Aspects of Sarcopenic Obesity.

Mazurkiewicz L, Czernikiewicz K, Grygiel-Gorniak B Genes (Basel). 2024; 15(2).

PMID: 38397196 PMC: 10888391. DOI: 10.3390/genes15020206.

The dual function of cGAS-STING signaling axis in liver diseases.

Li X, Qu J, Zhang Y, Liu R Acta Pharmacol Sin. 2024; 45(6):1115-1129.

PMID: 38233527 PMC: 11130165. DOI: 10.1038/s41401-023-01220-5.

Adenovirus 36 Infection in People Living with HIV-An Epidemiological Study of Seroprevalence and Associations with Cardiovascular Risk Factors.

Sapula M, Suchacz M, Kozlowska J, Cybula A, Siwak E, Krankowska D Viruses. 2022; 14(8).

PMID: 36016261 PMC: 9412590. DOI: 10.3390/v14081639.

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