» Articles » PMID: 28289950

Heavy and Standard Silicone Oil: Intraocular Inflammation

Overview
Journal Int Ophthalmol
Specialty Ophthalmology
Date 2017 Mar 15
PMID 28289950
Citations 20
Authors
Affiliations
Soon will be listed here.
Abstract

Purpose: Proliferative vitreoretinopathy in the inferior retina remains clinically challenging. Heavier-than-water intraocular tamponades have been developed to improve inferior tamponading properties, and their chemical compositions have been substantially improved over the years, in parallel with developments in vitrectomy instrumentation and surgical techniques. Herein we present an updated review of the clinical use of standard formulations and HSO, focusing on analysis of the intraocular inflammation associated with endotamponade agents, and comparison of the adverse effects of these agents on the physical and biological properties of the eye.

Methods: A detailed literature search was conducted on PubMed, EMBASE, Cochrane Library, and Google Scholar using the key words. Fifty-eight articles matched our inclusion criteria that were included in this systematic review.

Results: Perfluorocarbon liquids and partially fluorinated alkanes are associated with tamponade emulsification, intraocular inflammation, and rises in intraocular pressure, but these associations are not as strong when these substances are mixed with a heavy silicone oil (HSO). Two recently approved heavy silicone oil tamponades, Oxane HD and Densiron 68, are now available for use in clinical practice. While the complication spectrum of the new generation of these HSOs seems to be similar to that of conventional silicone oil tamponades, they provide better support for the inferior retina and the posterior pole.

Conclusion: Both regular and heavy silicone oils usually yield good success rates in cases of complicated retinal detachment. Decisions as to whether to utilize heavy or regular silicone oil should be made on a case-by-case basis.

Citing Articles

Risk Factors and Management of Intraocular Pressure Elevation After Vitrectomy Combined with Silicone Oil Tamponade.

Ge L, Su N, Fan W, Yuan S Int J Gen Med. 2024; 17:447-456.

PMID: 38333017 PMC: 10849908. DOI: 10.2147/IJGM.S446617.


Toxic posterior segment syndrome with retinal vasculitis likely caused by intraocular cotton fiber after vitreoretinal surgery - a case report.

Jayadev C, Gupta A, Gadde S, Venkatesh R BMC Ophthalmol. 2023; 23(1):464.

PMID: 37974099 PMC: 10655314. DOI: 10.1186/s12886-023-03212-9.


Anatomical and functional outcomes of short-term DensironXTRA heavy silicone oil for rhegmatogenous retinal detachments: a comparative case series.

Felfeli T, Murtaza F, Herman J, Pereira A, Mandelcorn M, Mandelcorn E Sci Rep. 2023; 13(1):3729.

PMID: 36878935 PMC: 9988839. DOI: 10.1038/s41598-023-30210-0.


Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery.

Confalonieri F, Josifovska N, Boix-Lemonche G, Stene-Johansen I, Bragadottir R, Lumi X Int J Mol Sci. 2023; 24(4).

PMID: 36834754 PMC: 9961686. DOI: 10.3390/ijms24043342.


Clinical Features and Possible Origin of Preretinal Deposits in Different Ocular Diseases and Events: A Narrative Review.

Cheng Y, Chen C, Zhang Z, Peng X Ophthalmol Ther. 2023; 12(2):737-753.

PMID: 36795322 PMC: 10011253. DOI: 10.1007/s40123-023-00674-4.


References
1.
Stefansson E . The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology. Acta Ophthalmol Scand. 2001; 79(5):435-40. DOI: 10.1034/j.1600-0420.2001.790502.x. View

2.
Wong D, van Meurs J, Stappler T, Groenewald C, Pearce I, McGalliard J . A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent. Br J Ophthalmol. 2005; 89(6):662-5. PMC: 1772688. DOI: 10.1136/bjo.2004.055178. View

3.
Vote B, Wheen L, Cluroe A, Teoh H, McGeorge A . Further evidence for proinflammatory nature of perfluorohexyloctane in the eye. Clin Exp Ophthalmol. 2003; 31(5):408-14. DOI: 10.1046/j.1442-9071.2003.00687.x. View

4.
Osterholz J, Winter M, Winkler J, Pfister G, Kovacs G, Dresp J . [Retinal damage by perfluorocarbon liquids - a question of specific gravity? Intraocular pressure peaks and shearing forces]. Klin Monbl Augenheilkd. 2009; 226(1):38-47. DOI: 10.1055/s-2008-1027764. View

5.
de Juan Jr E, Hardy M, Hatchell D, Hatchell M . The effect of intraocular silicone oil on anterior chamber oxygen pressure in cats. Arch Ophthalmol. 1986; 104(7):1063-4. DOI: 10.1001/archopht.1986.01050190121050. View