Repeated Intravenous Administration of Gadobutrol Does Not Lead to Increased Signal Intensity on Unenhanced T1-weighted Images-a Voxel-based Whole Brain Analysis

Overview

Journal Eur Radiol

Specialty Radiology

Date 2017 Mar 15

PMID 28289935

Citations 8

Authors

Soenke Langner

Marie-Luise Kromrey

Jens-Peter Kuehn

Matthias Grothe

Martin Domin

Affiliations

Soon will be listed here.

Abstract

Objectives: To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel-based whole-brain analysis.

Methods: In this retrospective single-centre study, 217 patients with a clinically isolated syndrome underwent baseline brain magnetic resonance imaging and at least one annual follow-up examination with intravenous administration of 0.1 mmol/kg body weight of gadobutrol. Using the "Diffeomorphic Anatomical Registration using Exponentiated Lie algebra" (DARTEL) normalisation process, tissue templates for grey matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were calculated, as were GM-CSF and WM-CSF ratios. Voxel-based whole-brain analysis was used to calculate the signal intensity for each voxel in each data set. Paired t-test was applied to test differences to baseline MRI for significance.

Results: Voxel-based whole-brain analysis demonstrated no significant changes in signal intensity of grey and white matter after up to five gadobutrol administrations. There was no significant change in GM-CSF and grey WM-CSF ratios.

Conclusion: Voxel-based whole-brain analysis did not demonstrate increased signal intensity of GM and WM on unenhanced T1-weighted images after repeated gadobutrol administration. The molecular structure of gadolinium-based contrast agent preparations may be an essential factor causing SI increase on unenhanced T1-weighted images.

Key Points: • Repeated administration of gadobutrol does not lead to increased signal intensity. • Voxel-based whole-brain analysis allows assessment of subtle changes in signal intensity. • Macrocyclic contrast agents in a proven dosage are safe.

Citing Articles

Evaluation of gadolinium deposition in cortical bone using three-dimensional ultrashort echo time quantitative susceptibility mapping: A preliminary study.

Zhang X, Zhou B, Chen Y, Cai Z, Guo Y, Wei Z NMR Biomed. 2023; 37(1):e5035.

PMID: 37721094 PMC: 10726698. DOI: 10.1002/nbm.5035.

Functional MRI in Radiology-A Personal Review.

Lotze M, Domin M, Langner S, Platz T Healthcare (Basel). 2022; 10(9).

PMID: 36141258 PMC: 9498519. DOI: 10.3390/healthcare10091646.

Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS.

Zivadinov R, Bergsland N, Hagemeier J, Ramasamy D, Dwyer M, Schweser F Neurology. 2019; 93(6):e611-e623.

PMID: 31285398 PMC: 6709999. DOI: 10.1212/WNL.0000000000007892.

Gadolinium-based contrast agents - review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients.

Blumfield E, Swenson D, Iyer R, Stanescu A Pediatr Radiol. 2019; 49(4):448-457.

PMID: 30923876 DOI: 10.1007/s00247-018-4304-8.

T1-weighted Grey Matter Signal Intensity Alterations After Multiple Administrations of Gadobutrol in Patients with Multiple Sclerosis, Referenced to White Matter.

Kelemen P, Alaoui J, Sieron D, Chan A, Kamm C, Heldner M Sci Rep. 2018; 8(1):16844.

PMID: 30442977 PMC: 6237839. DOI: 10.1038/s41598-018-35186-w.

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