The Role of the Saliva Antioxidant Barrier to Reactive Oxygen Species with Regard to Caries Development

Overview

Journal Redox Rep

Specialties Biochemistry
Biology
Endocrinology

Date 2017 Mar 15

PMID 28288542

Citations 10

Authors

A Jurczak

D Koscielniak

A Skalniak

M Papiez

P Vyhouskaya

W Krzysciak

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this study was to evaluate the role of the antioxidant barrier in the saliva of children with caries, and its impact on the colonization of cariogenic bacteria.

Methods: This is a cross-sectional study of 81 children aged 1-5 years. Antioxidant levels and salivary bacterial profiles were measured. Patients were divided into two groups as follows: initial stage decay, termed non-cavitated (1-2 in International Caries Detection and Assessment System (ICDAS)), and extensive decay, termed cavitated lesions (5-6 in ICDAS). The control group includes children without caries.

Results: The linear regression model demonstrated that the GSH, GSSG, GSH/GSSG, and total antioxidant capacity levels are influenced (P < 0.05) by: the stage of caries and the dominant bacterial strain. Compared with the other groups (P < 0.001), the highest antioxidant parameters were recorded in the saliva of patients with cavitated lesions.

Discussion: Our results indicate that the high levels of antioxidants in saliva increase significantly in children in line with the salivary cariogenic bacterial profiles and caries progression.

Citing Articles

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