A Review of the Potential of Phytochemicals from (Hook F.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2017 Mar 14

PMID 28286531

Citations 17

Authors

Richard Komakech

Youngmin Kang

Jun-Hwan Lee

Francis Omujal

Affiliations

Soon will be listed here.

Abstract

Prostate cancer remains one of the major causes of death worldwide. In view of the limited treatment options for patients with prostate cancer, preventive and treatment approaches based on natural compounds can play an integral role in tackling this disease. Recent evidence supports the beneficial effects of plant-derived phytochemicals as chemopreventive and chemotherapeutic agents for various cancers, including prostate cancer. has been used for generations in African traditional medicine to treat prostate cancer. This review examined the potential roles of the phytochemicals from , an endangered, sub-Saharan Africa plant in the chemoprevention and chemotherapy of prostate cancer. In vitro and in vivo studies have provided strong pharmacological evidence for antiprostate cancer activities of -derived phytochemicals. Through synergistic interactions between different effective phytochemicals, extracts have been shown to exhibit very strong antiandrogenic and antiangiogenic activities and have the ability to kill tumor cells via apoptotic pathways, prevent the proliferation of prostate cancer cells, and alter the signaling pathways required for the maintenance of prostate cancer cells. However, further preclinical and clinical studies ought to be done to advance and eventually use these promising phytochemicals for the prevention and chemotherapy of human prostate cancer.

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